Carocainide

Base Information

Chemical Name:Carocainide
CAS No.:66203-00-7
Molecular Formula:C18H25N3O5
Molecular Weight:363.414
Hs Code.:2934999090
European Community (EC) Number:266-233-7
UNII:T643E80J9K
DSSTox Substance ID:DTXSID00216381
Nikkaji Number:J39.454H
Wikidata:Q27289715
NCI Thesaurus Code:C77979
ChEMBL ID:CHEMBL289192
Mol file:66203-00-7.mol

Synonyms:1-(4,7-dimethoxy-6-(2-(1-pyrrolidinyl)ethoxy)-5-benzofuranyl)-3-methylurea;carocainide;MD 770207;MD-770207

Suppliers and Price of Carocainide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
CAROCAINIDE 95.00%
5MG
$ 501.89

Total 6 raw suppliers

Chemical Property of Carocainide

Chemical Property:

Vapor Pressure:2.67E-10mmHg at 25°C
Boiling Point:504.4°Cat760mmHg
Flash Point:258.8°C
PSA：85.20000
Density:1.242g/cm³
LogP:3.07770
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:363.17942091
Heavy Atom Count:26
Complexity:460

Purity/Quality:

99% ^*data from raw suppliers

CAROCAINIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC(=O)NC1=C(C2=C(C(=C1OCCN3CCCC3)OC)OC=C2)OC

Technology Process of Carocainide

There total 5 articles about Carocainide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 5050-41-9
N-(2-chloroethyl)-pyrrolidine

: 66203-89-2
N-(4,7-dimethoxy-6-hydroxy-5-benzofuranyl)-N'-methylurea

: 66203-00-7
N-<4,7-dimethoxy-6-(2-pyrrolidinoethoxy)-5-benzofuranyl>-N'-methylurea

Guidance literature:: With potassium carbonate; In acetonitrile; for 4h; Heating;
DOI:10.1021/jm00134a007

Reference yield:

: 52631-79-5
N-(4,7-dimethoxy-6-hydroxy-5-benzofuranyl)acetamide

: 66203-00-7
N-<4,7-dimethoxy-6-(2-pyrrolidinoethoxy)-5-benzofuranyl>-N'-methylurea

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / HCl / ethanol / 20 h / Heating

2: 89 percent / CHCl₃ / 2 h / Ambient temperature

3: 37 percent / K₂CO₃ / acetonitrile / 4 h / Heating

With hydrogenchloride; potassium carbonate; In ethanol; chloroform; acetonitrile;
DOI:10.1021/jm00134a007

Reference yield:

: 484-51-5
5-acetyl-6-hydroxy-4,7-dimethoxybenzofuran

: 66203-00-7
N-<4,7-dimethoxy-6-(2-pyrrolidinoethoxy)-5-benzofuranyl>-N'-methylurea

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / hydroxylamine hydrochloride, conc. NaOH / ethanol; H₂O / 6 h / Heating

2: 75 percent / aq. AcOH, HCl(g) / 0.5 h / 90 °C

3: 90 percent / HCl / ethanol / 20 h / Heating

4: 89 percent / CHCl₃ / 2 h / Ambient temperature

5: 37 percent / K₂CO₃ / acetonitrile / 4 h / Heating

With hydrogenchloride; sodium hydroxide; hydroxylamine hydrochloride; potassium carbonate; acetic acid; In ethanol; chloroform; water; acetonitrile;
DOI:10.1021/jm00134a007