3,4-Dimethoxy-o-phenylenediacetonitrile

Base Information

Chemical Name:3,4-Dimethoxy-o-phenylenediacetonitrile
CAS No.:85175-51-5
Molecular Formula:C12H12N2O2
Molecular Weight:216.239
Hs Code.:
DSSTox Substance ID:DTXSID501278770

Synonyms:SCHEMBL10648349;CLPUHDRCBSUDOU-UHFFFAOYSA-N;DTXSID501278770;3,4-dimethoxy-o-phenylenediacetonitrile;3,4-Dimethoxy-1,2-benzenediacetonitrile;3,4-dimethoxy-o-phenylene-diacetonitrile;85175-51-5

Suppliers and Price of 3,4-Dimethoxy-o-phenylenediacetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,4-Dimethoxy-o-phenylenediacetonitrile

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:216.089877630
Heavy Atom Count:16
Complexity:312

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C(=C(C=C1)CC#N)CC#N)OC

Technology Process of 3,4-Dimethoxy-o-phenylenediacetonitrile

There total 5 articles about 3,4-Dimethoxy-o-phenylenediacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875240-19-0
1,2-bis-chloromethyl-3,4-dimethoxy-benzene

: 151-50-8
potassium cyanide

: 85175-51-5
1,2-dicyanomethyl-3,4-dimethoxybenzene

Guidance literature:: With 2-ethoxy-ethanol; acetone;
DOI:10.1021/ja01154a060

Reference yield:

: 59276-33-4
veratraldehyde dimethyl acetal

: 85175-51-5
1,2-dicyanomethyl-3,4-dimethoxybenzene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi, 3.) H₃O⁽¹⁺⁾

2: 80 percent / lithium aluminium hydride / tetrahydrofuran / 12 h / Heating

3: 80 percent / sodium iodide, borontrifluoride etherate / acetonitrile / 0.33 h / Ambient temperature

4: 1.) 18-crown-6 / 1.) dimethyl sulfoxide, 60 deg C, 20 min, 2.) dimethyl sulfoxide, 60 deg C, 12 h

With lithium aluminium tetrahydride; n-butyllithium; 18-crown-6 ether; boron trifluoride diethyl etherate; oxonium; sodium iodide; In tetrahydrofuran; acetonitrile;
DOI:10.1002/jhet.5570300541

Reference yield:

: 519-05-1
opianic acid

: 85175-51-5
1,2-dicyanomethyl-3,4-dimethoxybenzene

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / lithium aluminium hydride / tetrahydrofuran / 12 h / Heating

2: 80 percent / sodium iodide, borontrifluoride etherate / acetonitrile / 0.33 h / Ambient temperature

3: 1.) 18-crown-6 / 1.) dimethyl sulfoxide, 60 deg C, 20 min, 2.) dimethyl sulfoxide, 60 deg C, 12 h

With lithium aluminium tetrahydride; 18-crown-6 ether; boron trifluoride diethyl etherate; sodium iodide; In tetrahydrofuran; acetonitrile;
DOI:10.1002/jhet.5570300541