2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-[[2-(4-methoxyphenyl)ethyl]methyl amino]propyl]-

Base Information

• Chemical Name: 2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-[[2-(4-methoxyphenyl)ethyl]methyl amino]propyl]-
• CAS No.: 85177-13-5
• Molecular Formula: C25H34N2O4
• Molecular Weight: 426.556
• Mol file: 85177-13-5.mol

Synonyms:

Chemical Property of 2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-[[2-(4-methoxyphenyl)ethyl]methyl amino]propyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-[[2-(4-methoxyphenyl)ethyl]methyl amino]propyl]-

There total 6 articles about 2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-[[2-(4-methoxyphenyl)ethyl]methyl amino]propyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7,8-Dimethoxy-3-(3-{[2-(4-methoxy-phenyl)-ethyl]-methyl-amino}-propyl)-1,3-dihydro-benzo[d]azepin-2-one (85175-70-8) → 1-[7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{4-methoxy-phenyl}-ethyl)-amino]-propane (85177-13-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 10h; under 3750.3 Torr; Ambient temperature;

DOI:10.1021/jm00167a033

Reference yield:

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) → 1-[7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{4-methoxy-phenyl}-ethyl)-amino]-propane (85177-13-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 81 percent / thionyl chloride / CH₂Cl₂ / 1 h / Heating

2: triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

3: 75 percent / glacial acetic acid, conc. HCl / 17 h / Ambient temperature

4: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min

5: 2 h / 90 - 95 °C

6: H₂ / Pd/C / acetic acid / 10 h / 3750.3 Torr / Ambient temperature

With hydrogenchloride; thionyl chloride; potassium tert-butylate; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In dichloromethane; acetic acid;

DOI:10.1021/jm00167a033

Reference yield:

7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one (73942-87-7) → 1-[7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{4-methoxy-phenyl}-ethyl)-amino]-propane (85177-13-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min

2: 2 h / 90 - 95 °C

3: H₂ / Pd/C / acetic acid / 10 h / 3750.3 Torr / Ambient temperature

With potassium tert-butylate; hydrogen; palladium on activated charcoal; In acetic acid;

DOI:10.1021/jm00167a033

upstream raw materials:

7,8-Dimethoxy-3-(3-{[2-(4-methoxy-phenyl)-ethyl]-methyl-amino}-propyl)-1,3-dihydro-benzo[d]azepin-2-one

(3,4-Dimethoxyphenyl)acetic acid

7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

3-(3-chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepine-2-one