3-(N-Boc)pentanedioic acid

Base Information

• Chemical Name: 3-(N-Boc)pentanedioic acid
• CAS No.: 85185-24-6
• Molecular Formula: C₁₀H₁₇NO₆
• Molecular Weight: 247.248
• Mol file: 85185-24-6.mol

Synonyms:DIMETHYL 3-(TERT-BUTOXYCARBONYLAMINO)PENTANEDIOATE;3-(N-Boc)pentanedioic acid;3-tert-butoxycarbonylaminopentanedioic acid;

Chemical Property of 3-(N-Boc)pentanedioic acid

Chemical Property:

• Boiling Point: 429.8±35.0 °C(Predicted)
• PKA: 4.00±0.10(Predicted)
• PSA: 112.93000
• Density: 1.264±0.06 g/cm3(Predicted)
• LogP: 1.22000

Purity/Quality:

99% ^*data from raw suppliers

3-((tert-Butoxycarbonyl)amino)pentanedioicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(N-Boc)pentanedioic acid

There total 6 articles about 3-(N-Boc)pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-5-(benzyloxy)-3-((tert-butoxycarbonyl)amino)-5-oxo-pentanoic acid → 3-pentanedioic acid (85185-24-6,127095-96-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h; Inert atmosphere;

Reference yield: 90.0%

3-aminopentanedioic acid (1948-48-7) + di-tert-butyl dicarbonate (24424-99-5) → 3-pentanedioic acid (85185-24-6,127095-96-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 120h;

Reference yield: 42.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-aminoglutaric acid hydrochloride → 3-pentanedioic acid (85185-24-6,127095-96-9)

Guidance literature:

With potassium hydroxide; In 1,4-dioxane; water; 1.) 20 deg C, 12 h, 2.) 60 deg C, 30 min;

DOI:10.1021/jm00151a011

upstream raw materials:

3-aminopentanedioic acid

di-tert-butyl dicarbonate

(2,6-Dioxo-tetrahydro-pyran-4-yl)-carbamic acid tert-butyl ester

glutaconic acid

Downstream raw materials:

N,N'-bis<3-<(benzyloxycarbonyl)amino>propyl>-3-pentanediamide

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