Acetamide, N-[3-acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-[(2,4-dimethoxy phenyl)methyl]-1,2-dihydro-2-oxo-1,8-naphthyridin-4-yl]-

Base Information

Chemical Name:Acetamide, N-[3-acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-[(2,4-dimethoxy phenyl)methyl]-1,2-dihydro-2-oxo-1,8-naphthyridin-4-yl]-
CAS No.:852315-27-6
Molecular Formula:C33H26Cl3N3O5
Molecular Weight:650.946
Hs Code.:

Acetamide,
N-[3-acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-[(2,4-dimethoxy
phenyl)methyl]-1,2-dihydro-2-oxo-1,8-naphthyridin-4-yl]-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Acetamide, N-[3-acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-[(2,4-dimethoxy phenyl)methyl]-1,2-dihydro-2-oxo-1,8-naphthyridin-4-yl]-

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Technology Process of Acetamide, N-[3-acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-[(2,4-dimethoxy phenyl)methyl]-1,2-dihydro-2-oxo-1,8-naphthyridin-4-yl]-

There total 10 articles about Acetamide, N-[3-acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-[(2,4-dimethoxy phenyl)methyl]-1,2-dihydro-2-oxo-1,8-naphthyridin-4-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-3-dimethylamino-Prop-2-en-1-one

: 852315-27-6
N-[3-acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-(2,4-dimethoxybenzyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 90 percent / NaOCH₃ / dimethylformamide / 95 °C

2.1: 81 percent / POCl₃ / Heating

3.1: tetrahydrofuran / 25 - 65 °C

4.1: MeMgBr / tetrahydrofuran

4.2: tetrahydrofuran

5.1: NaH / tetrahydrofuran / 0 - 25 °C

6.1: 85 °C

With methylmagnesium bromide; sodium methylate; sodium hydride; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.10.028

Reference yield:

: 611218-31-6
6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

: 852315-27-6
N-[3-acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-(2,4-dimethoxybenzyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 81 percent / POCl₃ / Heating

2.1: tetrahydrofuran / 25 - 65 °C

3.1: MeMgBr / tetrahydrofuran

3.2: tetrahydrofuran

4.1: NaH / tetrahydrofuran / 0 - 25 °C

5.1: 85 °C

With methylmagnesium bromide; sodium hydride; trichlorophosphate; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.10.028

Reference yield:

: 611218-68-9
2-chloro-6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyridine-3-carbonitrile

: 852315-27-6
N-[3-acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-(2,4-dimethoxybenzyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 25 - 65 °C

2.1: MeMgBr / tetrahydrofuran

2.2: tetrahydrofuran

3.1: NaH / tetrahydrofuran / 0 - 25 °C

4.1: 85 °C

With methylmagnesium bromide; sodium hydride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.10.028