3-amino-N-(pyridin-2-yl)benzamide

Base Information

• Chemical Name: 3-amino-N-(pyridin-2-yl)benzamide
• CAS No.: 85367-02-8
• Molecular Formula: C12H11N3O
• Molecular Weight: 213.239
• Hs Code.: 2933399090
• European Community (EC) Number: 873-510-1
• DSSTox Substance ID: DTXSID801305758
• Mol file: 85367-02-8.mol

Synonyms:3-amino-N-(pyridin-2-yl)benzamide;85367-02-8;3-amino-N-pyridin-2-ylbenzamide;3-Amino-N-pyridin-2-yl-benzamide;3-amino-N-2-pyridylbenzamide;SCHEMBL7096171;3-Amino-N-2-pyridinylbenzamide;benzamide,3-amino-n-2-pyridinyl-;DTXSID801305758;BBL028601;STK941384;3-Amino-N-(2-pyridinyl)benzamide #;Benzamide, 3-amino-N-(2-pyridyl)-;AKOS000133819;VS-08862;BB 0242968;CS-0253049;EN300-62367;Z239124864

Chemical Property of 3-amino-N-(pyridin-2-yl)benzamide

Chemical Property:

• PSA: 68.01000
• LogP: 2.57030
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 213.090211983
• Heavy Atom Count: 16
• Complexity: 244

Purity/Quality:

99% ^*data from raw suppliers

3-amino-N-(pyridin-2-yl)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)NC(=O)C2=CC(=CC=C2)N

Technology Process of 3-amino-N-(pyridin-2-yl)benzamide

There total 5 articles about 3-amino-N-(pyridin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.31%

2-aminopyridine (504-29-0) + m-nitrobenzoic acid chloride (121-90-4) → 3-amino-N-pyridin-2-yl-benzamide (85367-02-8)

Guidance literature:

2-aminopyridine; m-nitrobenzoic acid chloride; With pyridine; In dichloromethane; at 20 ℃;

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

Reference yield: 52.0%

3-nitro-N-(pyridin-2-yl)benzamide (85367-01-7) → 3-amino-N-pyridin-2-yl-benzamide (85367-02-8)

Guidance literature:

palladium-carbon; In ethanol;

Reference yield:

m-nitrobenzoic acid chloride (121-90-4) → 3-amino-N-pyridin-2-yl-benzamide (85367-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0.08 h / Ambient temperature

2: Sn, 6 N HCl / tetrahydrofuran / 1 h / 50 °C

With hydrogenchloride; tin; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00153a018

upstream raw materials:

3-nitro-N-(pyridin-2-yl)benzamide

2-aminopyridine

m-nitrobenzoic acid chloride

Downstream raw materials:

C₁₄H₁₆N₄O₃S

6-[3-(2-Pyridylcarbamoyl)phenylazo]-pyridoxal-5-phosphate