1-[2-(2-Chloroethoxy)ethoxy]-2-methoxybenzene

Base Information

• Chemical Name: 1-[2-(2-Chloroethoxy)ethoxy]-2-methoxybenzene
• CAS No.: 2287-32-3
• Molecular Formula: C11H15 Cl O3
• Molecular Weight: 230.691
• European Community (EC) Number: 218-927-6
• UNII: XSK4SNM3ZG
• DSSTox Substance ID: DTXSID00177408
• Nikkaji Number: J213.165J
• Wikidata: Q83047737
• Mol file: 2287-32-3.mol

Synonyms:1-[2-(2-chloroethoxy)ethoxy]-2-methoxybenzene;2287-32-3;EINECS 218-927-6;1-(2-(2-Chloroethoxy)ethoxy)-2-methoxybenzene;Benzene, 1-(2-(2-chloroethoxy)ethoxy)-2-methoxy-;Benzene, 1-[2-(2-chloroethoxy)ethoxy]-2-methoxy-;XSK4SNM3ZG;DTXSID00177408;AKOS012975639

Chemical Property of 1-[2-(2-Chloroethoxy)ethoxy]-2-methoxybenzene

Chemical Property:

• Vapor Pressure: 0.000564mmHg at 25°C
• Boiling Point: 321.3°Cat760mmHg
• Flash Point: 118.7°C
• PSA: 27.69000
• Density: 1.126g/cm³
• LogP: 2.32940
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 230.0709720
• Heavy Atom Count: 15
• Complexity: 155

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC=C1OCCOCCCl

Technology Process of 1-[2-(2-Chloroethoxy)ethoxy]-2-methoxybenzene

There total 2 articles about 1-[2-(2-Chloroethoxy)ethoxy]-2-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-phenol (90-05-1) + 3-oxa-1,5-dichloropentane (111-44-4) → 1-[2-(2-chloroethoxy)ethoxy]-2-methoxybenzene (2287-32-3)

Guidance literature:

Multistep reaction; (i) NaOH, HOCH₂CH₂OH, (ii) /BRN= 605317/;

DOI:10.1021/jm00328a035

Reference yield:

→ 1-[2-(2-chloroethoxy)ethoxy]-2-methoxybenzene (2287-32-3)

Guidance literature:

CH3OC6H4OH, (ClCH2CH2)2O;

Reference yield: 54.0%

1-[2-(2-chloroethoxy)ethoxy]-2-methoxybenzene (2287-32-3) + (2S)-2-(3-pyridyl)piperidine hydrochloride (53912-89-3) + oxalic acid (144-62-7,97993-78-7) → (S)-3-(1-{2-[2-(2-methoxyphenoxy)ethoxy]ethyl}piperidin-2-yl)pyridine oxalate (1446339-63-4)

Guidance literature:

1-[2-(2-chloroethoxy)ethoxy]-2-methoxybenzene; (2S)-2-(3-pyridyl)piperidine hydrochloride; With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 60 ℃; for 24h;

oxalic acid; In diethyl ether; at -20 ℃;

DOI:10.1007/s10600-013-0585-1

upstream raw materials:

2-methoxy-phenol

3-oxa-1,5-dichloropentane

Downstream raw materials:

1-Diaethylamino-14-(2-methoxy-phenoxy)-3,6,9,12-tetraoxa-tetradecan

1-Diaethylamino-17-(2-methoxy-phenoxy)-3,6,9,12,15-pentaoxa-heptadecan

1-Diaethylamino-20-(2-methoxy-phenoxy)-3,6,9,12,15,18-hexaoxa-eikosan

Tris<5-(2-methoxyphenoxy)-3-oxapentyl>amin

Refernces