(4-BENZYLOXYBUTYL)TRIPHENYLPHOSPHONIUM BROMIDE

Base Information

• Chemical Name: (4-BENZYLOXYBUTYL)TRIPHENYLPHOSPHONIUM BROMIDE
• CAS No.: 85514-52-9
• Molecular Formula: C29H30OP.Br
• Molecular Weight: 505.434
• Hs Code.: 2931900090
• Mol file: 85514-52-9.mol

Synonyms:[Ph3P(CH2)4OBn](+)Br(-);(4-benzyloxy-butyl)-triphenyl-phosphonium bromide;

Chemical Property of (4-BENZYLOXYBUTYL)TRIPHENYLPHOSPHONIUM BROMIDE

Chemical Property:

• PSA: 22.82000
• LogP: 2.98150

Purity/Quality:

97% ^*data from raw suppliers

(4-BENZYLOXYBUTYL)TRIPHENYLPHOSPHONIUM BROMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-BENZYLOXYBUTYL)TRIPHENYLPHOSPHONIUM BROMIDE

There total 2 articles about (4-BENZYLOXYBUTYL)TRIPHENYLPHOSPHONIUM BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4-bromobutyl benzyl ether (60789-54-0) + triphenylphosphine (603-35-0) → (4-(benzyloxy)butyl)triphenylphosphonium bromide (85514-52-9)

Guidance literature:

4-bromobutyl benzyl ether; triphenylphosphine; In acetonitrile; for 164h; Reflux;

With potassium hydroxide; In tetrahydrofuran; water; for 3.5h;

DOI:10.1016/j.tetlet.2009.06.068

Reference yield:

4-bromobutyl benzyl ether (60789-54-0) + triphenylphosphine (603-35-0) → benzyltriphenylphosphonium bromide (1449-46-3) + (4-(benzyloxy)butyl)triphenylphosphonium bromide (85514-52-9)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; for 100h; Reflux;

DOI:10.1016/j.tetlet.2009.06.068

Reference yield: 95.0%

(2S,4S,5R)-1-tert-butoxycarbonyl-2-(2-oxoethyl)-4,5-epoxypiperidine (1365993-60-7) + (4-(benzyloxy)butyl)triphenylphosphonium bromide (85514-52-9) → (2R,4S,5R,Z)-1-tert-butoxycarbonyl-2-(6-benzyloxyhex-2-enyl)-4,5-epoxypiperidine (1365993-61-8)

Guidance literature:

(4-(benzyloxy)butyl)triphenylphosphonium bromide; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 0.666667h; Inert atmosphere;

(2S,4S,5R)-1-tert-butoxycarbonyl-2-(2-oxoethyl)-4,5-epoxypiperidine; In tetrahydrofuran; at 0 - 20 ℃; for 16h; optical yield given as %de; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ol300209s

upstream raw materials:

4-bromobutyl benzyl ether

triphenylphosphine

Downstream raw materials:

4-(benzyloxy)-1-phenylbutan-1-ol

(2R,4S,5R,Z)-1-tert-butoxycarbonyl-2-(6-benzyloxyhex-2-enyl)-4,5-epoxypiperidine

C₂₃H₃₂O₆