14,15-secocholestane

Base Information

• Chemical Name: 14,15-secocholestane
• CAS No.: 131896-90-7
• Molecular Formula: C₂₇H₅₀
• Molecular Weight: 374.694
• Mol file: 131896-90-7.mol

Synonyms:14,15-Secocholestane,(5a)-; Phenanthrene,2-(1-ethyl-2,6-dimethylheptyl)tetradecahydro-2,4b-dimethyl-, [2S-[2a(1S*,2S*),4aa,4bb,8aa,10ab]]- (9CI)

Chemical Property of 14,15-secocholestane

Chemical Property:

• Vapor Pressure: 1.76E-07mmHg at 25°C
• Boiling Point: 438.5°C at 760 mmHg
• Flash Point: 211°C
• PSA: 0.00000
• Density: 0.874g/cm³
• LogP: 8.88790

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 14,15-secocholestane

There total 3 articles about 14,15-secocholestane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5α-(17R,20R)-14,15-secocholest-15-yl tosylate → 5α-(17R,20R)-14,15-secocholestane (131896-90-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Heating;

DOI:10.1016/0039-128X(90)90042-A

Reference yield:

(3R,4R)-3-((2S,4aS,4bS,8aR,10aS)-2,4b-Dimethyl-tetradecahydro-phenanthren-2-yl)-4,8-dimethyl-nonan-1-ol (131768-60-0) → 5α-(17R,20R)-14,15-secocholestane (131896-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 6 mg / pyridine / 16 h / Ambient temperature

2: 6 mg / lithium aluminum hydride / tetrahydrofuran / 3 h / Heating

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/0039-128X(90)90042-A

Reference yield:

5α-14,15-secocholesta-3,14,15-trione (131768-57-5) → 5α-(17R,20R)-14,15-secocholestane (131896-90-7) + (3R,4R)-3-((2S,4aS,4bS,8aR,10aS)-2,4b-Dimethyl-tetradecahydro-phenanthren-2-yl)-4,8-dimethyl-nonan-1-ol (131768-60-0) + C27H46O2 (131768-59-7) + C27H44O3 (131768-58-6)

Guidance literature:

With hydrogenchloride; amalgamated zinc; In ethanol; for 3.5h; Yield given; Heating;

DOI:10.1016/0039-128X(90)90042-A

upstream raw materials:

5α-14,15-secocholesta-3,14,15-trione

(3R,4R)-3-((2S,4aS,4bS,8aR,10aS)-2,4b-Dimethyl-tetradecahydro-phenanthren-2-yl)-4,8-dimethyl-nonan-1-ol

Refernces