2-(4-morpholinocarbonyl)-3-phenylcyclopropane-2-(1-methylethyl)-5-methylcyclohexyl ester

Base Information

Chemical Name:2-(4-morpholinocarbonyl)-3-phenylcyclopropane-2-(1-methylethyl)-5-methylcyclohexyl ester
CAS No.:135588-56-6
Molecular Formula:C25H35 N O4
Molecular Weight:413.55
Hs Code.:
Mol file:135588-56-6.mol

Synonyms:2-(4-morpholinocarbonyl)-3-phenylcyclopropane-2-(1-methylethyl)-5-methylcyclohexyl ester

Suppliers and Price of 2-(4-morpholinocarbonyl)-3-phenylcyclopropane-2-(1-methylethyl)-5-methylcyclohexyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 2-(4-morpholinocarbonyl)-3-phenylcyclopropane-2-(1-methylethyl)-5-methylcyclohexyl ester

Chemical Property:

Vapor Pressure:3.06E-12mmHg at 25°C
Boiling Point:552.3°Cat760mmHg
Flash Point:287.8°C
PSA：55.84000
Density:1.14g/cm³
LogP:3.81690

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(4-morpholinocarbonyl)-3-phenylcyclopropane-2-(1-methylethyl)-5-methylcyclohexyl ester

There total 5 articles about 2-(4-morpholinocarbonyl)-3-phenylcyclopropane-2-(1-methylethyl)-5-methylcyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 15356-60-2
(1S,2R,5S)-(+)-menthol

: 141042-69-5
<1R-(1α,2β,3β)>-2-(4-morpholinylcarbonyl)-3-phenylcyclopropanecarboxylic acid

: 135588-56-6
<1R-<1α(1R*,2R*,3S*),2β,5α>>-2-(4-morpholinylcarbonyl)-3-phenylcyclopropanecarboxylic acid (-)-menthol ester

Guidance literature:: With dmap; 2`,3`-dideoxycytidine; In dichloromethane; N,N-dimethyl-formamide; for 72h; Ambient temperature;
DOI:10.1021/jm00088a005

Reference yield:

: 132435-60-0
(1R-(1α,5α,6α))-6-phenyl-3-oxabicyclo[3.1.0]hexan-2-one

: 135588-56-6
<1R-<1α(1R*,2R*,3S*),2β,5α>>-2-(4-morpholinylcarbonyl)-3-phenylcyclopropanecarboxylic acid (-)-menthol ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) trimethylaluminum / 1.) CH₂Cl₂, hexane, RT, 20 min, 2.) CH₂Cl₂, hexane, 40 deg C, 40 h

2: 68 percent / pyridinium chlorochromate / CH₂Cl₂ / 48 h / Ambient temperature

3: 80 percent / K₂CO₃ / methanol / 24 h / Ambient temperature

4: 76 percent / 8N Jones' reagent / acetone / 2 h / 0 - 5 °C

5: 46 percent / DDC, DMAP / CH₂Cl₂; dimethylformamide / 72 h / Ambient temperature

With dmap; jones' reagent; trimethylaluminum; potassium carbonate; 2`,3`-dideoxycytidine; pyridinium chlorochromate; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00088a005

Reference yield:

: 140926-05-2
<1R-(1α,2α,3α)>-1-(4-morpholinylcarbonyl)-3-phenylcyclopropane-2-carboxaldehyde

: 135588-56-6
<1R-<1α(1R*,2R*,3S*),2β,5α>>-2-(4-morpholinylcarbonyl)-3-phenylcyclopropanecarboxylic acid (-)-menthol ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / K₂CO₃ / methanol / 24 h / Ambient temperature

2: 76 percent / 8N Jones' reagent / acetone / 2 h / 0 - 5 °C

3: 46 percent / DDC, DMAP / CH₂Cl₂; dimethylformamide / 72 h / Ambient temperature

With dmap; jones' reagent; potassium carbonate; 2`,3`-dideoxycytidine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00088a005