5'-methylthioinosine

Base Information

• Chemical Name: 5'-methylthioinosine
• CAS No.: 17298-58-7
• Molecular Formula: C11H14 N4 O4 S
• Molecular Weight: 298.32
• Mol file: 17298-58-7.mol

Synonyms:5'-Deoxy-5'-methylthioinosine;5'-Methylthioinosine

Chemical Property of 5'-methylthioinosine

Chemical Property:

• Boiling Point: 686.7°Cat760mmHg
• Flash Point: 369.1°C
• PSA: 138.56000
• Density: 1.85g/cm³
• LogP: -0.89820

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5'-methylthioinosine

There total 9 articles about 5'-methylthioinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5'-Deoxy-5'-methylthioadenosine (2457-80-9) → 5'-S-methyl-5'-thioinosine (17298-58-7)

Guidance literature:

With phosphate buffer pH 6.8; ethanethiol; In water; α-amylase from Aspergillus oryzae;

DOI:10.1080/15257779408013249

Reference yield: 66.0%

Acetic acid (2R,3R,4S,5S)-4-acetoxy-5-methylsulfanylmethyl-2-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester → 5'-S-methyl-5'-thioinosine (17298-58-7)

Guidance literature:

With ammonia; In methanol; at 0 ℃; for 2h;

DOI:10.1080/15257779408013249

Reference yield:

2',3'-Di-O-acetyl-5'-deoxy-5'-(methylthio)adenosine (119771-17-4) → 5'-S-methyl-5'-thioinosine (17298-58-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 33 percent / tert-butyl nitrite / ethyl acetate / 5 h / Ambient temperature

2: 66 percent / NH₃ / methanol / 2 h / 0 °C

With tert.-butylnitrite; ammonia; In methanol; ethyl acetate;

DOI:10.1080/15257779408013249

upstream raw materials:

5'-Deoxy-5'-methylthioadenosine

2',3'-Di-O-acetyl-5'-deoxy-5'-(methylthio)adenosine

2',3'-isopropylidene adenosine

9-((3aR,4R,6S,6aS)-2,2-dimethyl-6-((methylthio)methyl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine