1,3-Dimethyl-5-iodopyrazole

Base Information

• Chemical Name: 1,3-Dimethyl-5-iodopyrazole
• CAS No.: 85779-98-2
• Molecular Formula: C5H7IN2
• Molecular Weight: 222.02700
• Mol file: 85779-98-2.mol

Synonyms:

Chemical Property of 1,3-Dimethyl-5-iodopyrazole

Chemical Property:

• PSA: 17.82000
• LogP: 1.33310

Purity/Quality:

98%min ^*data from raw suppliers

1,3-Dimethyl-5-iodopyrazole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Dimethyl-5-iodopyrazole

There total 1 articles about 1,3-Dimethyl-5-iodopyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1,3-dimethyl-1H-pyrazole (694-48-4) → 5-iodo-1,3-dimethylpyrazole (85779-98-2)

Guidance literature:

With n-butyllithium; iodine;

DOI:10.1007/BF00953123

Reference yield:

5-iodo-1,3-dimethylpyrazole (85779-98-2) → 1,3-dimethyl-5-phenylpyrrolo<3,2-c>pyrazole

Guidance literature:

Multi-step reaction with 3 steps

1: 80.5 percent / conc. H₂SO₄, fuming HNO₃ / 0.75 h / 85 °C

2: 53 percent / SnCl₂, conc. HCl / 1 h / 60 °C

3: 37.5 percent / dimethylformamide / 2 h / Heating

With hydrogenchloride; sulfuric acid; nitric acid; tin(ll) chloride; In N,N-dimethyl-formamide;

DOI:10.1007/BF00953123

Reference yield:

5-iodo-1,3-dimethylpyrazole (85779-98-2) → 4-amino-5-phenylethynyl-1,3-dimethylpyrazole (85779-96-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 80.5 percent / conc. H₂SO₄, fuming HNO₃ / 0.75 h / 85 °C

2: 53 percent / SnCl₂, conc. HCl / 1 h / 60 °C

3: 82 percent / CuI, Pd(PPh₃)2Cl₂, Et₃N / 1.) 30 deg C, 3 h, 2.) 50 deg C, 3 h

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sulfuric acid; nitric acid; triethylamine; tin(ll) chloride;

DOI:10.1007/BF00953123

upstream raw materials:

1,3-dimethyl-1H-pyrazole

Downstream raw materials:

4-amino-5-phenylethynyl-1,3-dimethylpyrazole

Refernces