1,4,7,10-Tetraazacyclododecane-1,4,7-tricarboxylic acid, 10-[2-[[(2S)-2-amino-1-oxo-3-phenylpropyl]amino]ethyl]-, tris(1,1-dimethylethyl) ester

Base Information

Chemical Name:1,4,7,10-Tetraazacyclododecane-1,4,7-tricarboxylic acid, 10-[2-[[(2S)-2-amino-1-oxo-3-phenylpropyl]amino]ethyl]-, tris(1,1-dimethylethyl) ester
CAS No.:858131-90-5
Molecular Formula:C34H58N6O7
Molecular Weight:662.871
Hs Code.:

1,4,7,10-Tetraazacyclododecane-1,4,7-tricarboxylic acid,
10-[2-[[(2S)-2-amino-1-oxo-3-phenylpropyl]amino]ethyl]-,
tris(1,1-dimethylethyl) ester

Synonyms:

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Chemical Property of 1,4,7,10-Tetraazacyclododecane-1,4,7-tricarboxylic acid, 10-[2-[[(2S)-2-amino-1-oxo-3-phenylpropyl]amino]ethyl]-, tris(1,1-dimethylethyl) ester

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MSDS Files:: SDS file from LookChem

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Technology Process of 1,4,7,10-Tetraazacyclododecane-1,4,7-tricarboxylic acid, 10-[2-[[(2S)-2-amino-1-oxo-3-phenylpropyl]amino]ethyl]-, tris(1,1-dimethylethyl) ester

There total 2 articles about 1,4,7,10-Tetraazacyclododecane-1,4,7-tricarboxylic acid, 10-[2-[[(2S)-2-amino-1-oxo-3-phenylpropyl]amino]ethyl]-, tris(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 858131-87-0
10-{2-[2-(9H-fluoren-9-yl-methoxycarbonylamino)-2-benzyl-acetylamino]-ethyl}-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester

: 858131-90-5
10-[2-(2-amino-3-phenylpropionylamino)-ethyl]-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In acetonitrile; at 20 ℃; for 0.283333h;
DOI:10.1016/j.tet.2005.03.081

Reference yield:

: 437658-58-7
10-(2-aminoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

: 858131-90-5
10-[2-(2-amino-3-phenylpropionylamino)-ethyl]-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / HOAt; HATU; collidine / dimethylformamide; CH₂Cl₂ / 48 h / 40 °C

2: 89 percent / tetrabutylammonium fluoride trihydrate / acetonitrile / 0.28 h / 20 °C

With 2,3,5-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; tetrabutyl ammonium fluoride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2005.03.081

Reference yield: 86.0%

: 858131-90-5
10-[2-(2-amino-3-phenylpropionylamino)-ethyl]-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester

: 97935-71-2
1-benzyl-pyridinium bromide-3-carboxylic acid

: 1-benzyl-3-{2-phenyl-1-[2-(4,7,10-tris-tert-butoxycarbonyl-1,4,7,10-tetraaza-cyclododec-1-yl)-ethylcarbomoyl]-ethylcarbamoyl}-pyridinium bromide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.tet.2005.03.081