[S-(R,S)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol

Base Information Edit

Chemical Name:[S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol
CAS No.:23942-99-6
Molecular Formula:C22H27 N O7
Molecular Weight:417.459
Hs Code.:
Mol file:23942-99-6.mol

Synonyms:1,2-Benzenedimethanol,3,4-dimethoxy-a1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-,[S-(R*,S*)]-; a-Narcotinediol(8CI); 1,3-Dioxolo[4,5-g]isoquinoline, 1,2-benzenedimethanol deriv.;(-)-Narcotinediol; (-)-a-Narcotinediol; NSC 132826; NSC 279531; Narcotinediol

Suppliers and Price of [S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
(-)-α-Narcotinediol
100 mg
$ 2200.00

Total 5 raw suppliers

Chemical Property of [S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol Edit

Chemical Property:

Melting Point:130-132 °C(Solv: ethyl acetate (141-78-6); ethyl ether (60-29-7))
Boiling Point:570.3°Cat760mmHg
PKA:13.25±0.20(Predicted)
Flash Point:298.7°C
PSA：89.85000
Density:1.3g/cm³
LogP:2.13390

Purity/Quality:

99% ^*data from raw suppliers

(-)-α-Narcotinediol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (-)-α-Narcotinediol is a Narcotine derivative, a noscapinoid class of microtubule binding compounds that alter microtubule dynamics without affecting tubulin polymer mass. Noscapinoids show great promise as chemotherapeutic agents for the treatment of human cancers. Unlike Narcotine, (-)-α-Narcotinediol deos not inhibit small-intestinal transport in rats.

Technology Process of [S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol

There total 6 articles about [S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 106982-93-8
(+)-papaveroxinoline

: 23942-99-6
(-)-α-narcotinediol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Ambient temperature;

Reference yield: 80.0%

: 128-62-1
noscapine

: 23942-99-6
(-)-α-narcotinediol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 35 ℃; for 2h;

Reference yield:

: 106982-95-0
narcotinediol diacetate

: 23942-99-6
(-)-α-narcotinediol

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / 6 M HCl / aq. ethanol / Ambient temperature; 3-5 d

2: 96 percent / LiAlH₄ / tetrahydrofuran / 1 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; ethanol;