Morpholine, 4-[(1-hydroxy-2-naphthalenyl)carbonyl]-

Base Information

Chemical Name:Morpholine, 4-[(1-hydroxy-2-naphthalenyl)carbonyl]-
CAS No.:33079-11-7
Molecular Formula:C₁₅H₁₅NO₃
Molecular Weight:257.289
Hs Code.:2934999090
DSSTox Substance ID:DTXSID2067745
Nikkaji Number:J422.287C
Wikidata:Q81994389
ChEMBL ID:CHEMBL4573474
Mol file:33079-11-7.mol

Synonyms:33079-11-7;Morpholine, 4-[(1-hydroxy-2-naphthalenyl)carbonyl]-;1-Hydroxy-2-naphthoic acid morpholide;(1-hydroxynaphthalen-2-yl)-morpholin-4-ylmethanone;Methanone, (1-hydroxy-2-naphthalenyl)-4-morpholinyl-;Morpholine, 4-(1-hydroxy-2-naphthoyl)-;Morpholine, 4-((1-hydroxy-2-naphthalenyl)carbonyl)-;CHEMBL4573474;DTXSID2067745;4-(1-Hydroxy-2-naphthoyl)morpholine;AKOS000207120;Z79434118

Suppliers and Price of Morpholine, 4-[(1-hydroxy-2-naphthalenyl)carbonyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Morpholine, 4-[(1-hydroxy-2-naphthalenyl)carbonyl]-

Chemical Property:

Vapor Pressure:3.29E-10mmHg at 25°C
Melting Point:156-157 °C
Boiling Point:489.6°Cat760mmHg
PKA:8.15±0.50(Predicted)
Flash Point:249.9°C
PSA：49.77000
Density:1.298g/cm³
LogP:1.95570
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:257.10519334
Heavy Atom Count:19
Complexity:327

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COCCN1C(=O)C2=C(C3=CC=CC=C3C=C2)O

Technology Process of Morpholine, 4-[(1-hydroxy-2-naphthalenyl)carbonyl]-

There total 4 articles about Morpholine, 4-[(1-hydroxy-2-naphthalenyl)carbonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 347370-63-2
C₁₅H₁₅NO₃

: 33079-11-7
(1-hydroxynaphthalen-2-yl)(morpholin-4-yl)methanone

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1055/s-0029-1217991

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 38077-69-9
1-hydroxy-2-naphthoyl chloride

: 1388146-99-3
2-(morpholin-4-carbonyl)naphthalen-1-yl 1-hydroxy-2-naphthoate

: 33079-11-7
(1-hydroxynaphthalen-2-yl)(morpholin-4-yl)methanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.dyepig.2011.07.013

Reference yield:

: 86-48-6
1-hydroxy-2-naphthoic acid

: 33079-11-7
(1-hydroxynaphthalen-2-yl)(morpholin-4-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / n-heptane; N,N-dimethyl-formamide / 4 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In n-heptane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.dyepig.2011.07.013