Naronapride

Base Information

Chemical Name:Naronapride
CAS No.:860174-12-5
Molecular Formula:C27H41ClN4O5
Molecular Weight:537.099
Hs Code.:
UNII:058896B00B
DSSTox Substance ID:DTXSID401006590
Wikidata:Q27236096
NCI Thesaurus Code:C175157
Metabolomics Workbench ID:149512
ChEMBL ID:CHEMBL2103858

Synonyms:(3R)-1-azabicyclo(2.2.2)oct-3-yl 6-((3S,4R)-4-((4-amino-5-chloro-2-methoxybenzoyl)amino)-3-methoxy-1-piperidinyl)hexanoate;ATI 7505;ATI-7505;ATI7505;naronapride

Suppliers and Price of Naronapride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Naronapride

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:12
Exact Mass:536.2765481
Heavy Atom Count:37
Complexity:752

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCCCC(=O)OC3CN4CCC3CC4
Isomeric SMILES:CO[C@H]1CN(CC[C@H]1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCCCC(=O)O[C@H]3CN4CCC3CC4
Recent ClinicalTrials:Different Doses of Naronapride vs. Placebo in Gastroparesis
Recent EU Clinical Trials:Double-blind, randomised, placebo-controlled, dose-finding phase IIb trial to evaluate the efficacy, safety, and tolerability of a 12-week-treatment with Naronapride in adult participants with at least moderate idiopathic or diabetic gastroparesis

Technology Process of Naronapride

There total 21 articles about Naronapride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3R)-1-azabicyclo[2.2.2]octan-3-ol hydrochloride

: [14C]-ATI-7500

: 860174-12-5
Naronapride

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 50 ℃; Product distribution / selectivity;

Reference yield:

: ethyl 6-((3S,4R)-4-(4-amino-5-chloro-2-methoxybenzamido)-3-methoxypiperidin-1-yl)hexanoate

: 25333-42-0
(R)-quinuclidin-3-ol

: 860174-12-5
Naronapride

Guidance literature:: With titanium(IV) tetraethanolate; In toluene; at 91 ℃; for 33h;

Reference yield:

: 860169-83-1
(R)-quinuclidin-3-yl 6-((3S,4R)-4-amino-3-methoxypiperidin-1-yl)hexanoate

: 860174-12-5
Naronapride

Guidance literature:: 4-amino-5-chloro-2-methoxybenzoic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at 20 ℃; for 0.5h;

(R)-quinuclidin-3-yl 6-((3S,4R)-4-amino-3-methoxypiperidin-1-yl)hexanoate; In tetrahydrofuran; at 20 ℃; for 14h; Product distribution / selectivity;