5-phenyl-1H-indole-7-carboxamide

Base Information

Chemical Name:5-phenyl-1H-indole-7-carboxamide
CAS No.:860625-06-5
Molecular Formula:C15H12N2O
Molecular Weight:236.273
Hs Code.:
DSSTox Substance ID:DTXSID80458767
Wikidata:Q82282282
ChEMBL ID:CHEMBL1761499

Synonyms:5-phenyl-1H-indole-7-carboxamide;860625-06-5;CHEMBL1761499;SCHEMBL3802579;DTXSID80458767;IOAHDHUZGJTQFJ-UHFFFAOYSA-N;BDBM50418172;FT-0703829

Suppliers and Price of 5-phenyl-1H-indole-7-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 5-phenyl-1H-indole-7-carboxamide

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:236.094963011
Heavy Atom Count:18
Complexity:312

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CC(=C3C(=C2)C=CN3)C(=O)N

Technology Process of 5-phenyl-1H-indole-7-carboxamide

There total 7 articles about 5-phenyl-1H-indole-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 860625-58-7
1,1-dimethylethyl 7-[(bis{[(1,1-dimethylethyl)oxy]carbonyl}amino)carbonyl]-5-phenyl-1 H-indole-1-carboxylate

: 860625-06-5
5-phenyl-1H-indole-7-carboxamide

Guidance literature:: With hydrogenchloride; In ethanol; water; at 150 ℃; for 0.0833333h; Microwave;

Reference yield:

: 860625-61-2
1,1-dimethylethyl 7-[({[(1,1-dimethylethyl)oxy]carbonyl}amino)carbonyl]-5-phenyl-1H-indole-1-carboxylate

: 860625-06-5
5-phenyl-1H-indole-7-carboxamide

Guidance literature:: With hydrogenchloride; In ethanol; water; at 150 ℃; for 0.0833333h; Microwave;

Reference yield:

: 1065181-52-3
1-(1,1-dimethylethyl) 7-ethyl 2,3-dihydro-1H-indole-1,7-dicarboxylate

: 860625-06-5
5-phenyl-1H-indole-7-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / dichloromethane / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / chloroform / 2 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide / methanol; water / 50 h / Reflux; Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonia / methanol; dichloromethane / 16 h / 20 °C / Inert atmosphere

5.1: potassium phosphate; 2'-(dimethylamino)-2-biphenylyl-palladium(II) chloride dinorbornylphosphine complex / water; 1,4-dioxane / 3 h / Inert atmosphere; Reflux

With potassium phosphate; N-Bromosuccinimide; 2'-(dimethylamino)-2-biphenylyl-palladium(II) chloride dinorbornylphosphine complex; ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hydroxide; In 1,4-dioxane; methanol; dichloromethane; chloroform; water; 5.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acsmedchemlett.8b00291