Glycine, N-[[5-[[[(1S)-1-[(1,1-dimethylethoxy)carbonyl]propyl]amino]carbonyl]-3-[( 7-methoxy-2-phenyl-4-quinolinyl)oxy]-1-cyclopenten-1-yl]carbonyl]-D-valyl -2-cyclohexyl-, methyl ester, (2R)-

Base Information

Chemical Name:Glycine, N-[[5-[[[(1S)-1-[(1,1-dimethylethoxy)carbonyl]propyl]amino]carbonyl]-3-[( 7-methoxy-2-phenyl-4-quinolinyl)oxy]-1-cyclopenten-1-yl]carbonyl]-D-valyl -2-cyclohexyl-, methyl ester, (2R)-
CAS No.:862174-44-5
Molecular Formula:C45H58N4O9
Molecular Weight:798.977
Hs Code.:

Glycine,
N-[[5-[[[(1S)-1-[(1,1-dimethylethoxy)carbonyl]propyl]amino]carbonyl]-3-[(
7-methoxy-2-phenyl-4-quinolinyl)oxy]-1-cyclopenten-1-yl]carbonyl]-D-valyl
-2-cyclohexyl-, methyl ester, (2R)-

Synonyms:

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Chemical Property of Glycine, N-[[5-[[[(1S)-1-[(1,1-dimethylethoxy)carbonyl]propyl]amino]carbonyl]-3-[( 7-methoxy-2-phenyl-4-quinolinyl)oxy]-1-cyclopenten-1-yl]carbonyl]-D-valyl -2-cyclohexyl-, methyl ester, (2R)-

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Technology Process of Glycine, N-[[5-[[[(1S)-1-[(1,1-dimethylethoxy)carbonyl]propyl]amino]carbonyl]-3-[( 7-methoxy-2-phenyl-4-quinolinyl)oxy]-1-cyclopenten-1-yl]carbonyl]-D-valyl -2-cyclohexyl-, methyl ester, (2R)-

There total 6 articles about Glycine, N-[[5-[[[(1S)-1-[(1,1-dimethylethoxy)carbonyl]propyl]amino]carbonyl]-3-[( 7-methoxy-2-phenyl-4-quinolinyl)oxy]-1-cyclopenten-1-yl]carbonyl]-D-valyl -2-cyclohexyl-, methyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 862175-14-2
(R)-((R)-2-amino-3-methylbutyrylamino)cyclohexylacetic acid methyl ester

: trans-5-[((S)-1-tert-butoxycarbonylpropyl)carbamoyl]-3-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-enecarboxylic acid

: 862174-44-5
(S)-2-{[trans-2-{(R)-1-[((R)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2-methylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-enecarbonyl]amino}butyric acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1016/j.bmc.2006.10.044

Reference yield:

: (R)-((R)-2-benzyloxycarbonylamino-3-methylbutyrylamino)cyclohexylacetic acid methyl ester

: 862174-44-5
(S)-2-{[trans-2-{(R)-1-[((R)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2-methylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-enecarbonyl]amino}butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd-C / ethanol / 2.5 h

2: 66 percent / O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; ethyldiisopropylamine / dimethylformamide / 0 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.10.044

Reference yield:

: 1685-33-2
N-[(benzyloxy)carbonyl]-D-valine

: 862174-44-5
(S)-2-{[trans-2-{(R)-1-[((R)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2-methylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-enecarbonyl]amino}butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / O-(7-azabenzotriazol-1-yl)-N,N,N'N'-tetramethyluronium PF₆; ethyldiisopropylamine / dimethylformamide / 16 h / cooling

2: 100 percent / H₂ / Pd-C / ethanol / 2.5 h

3: 66 percent / O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; ethyldiisopropylamine / dimethylformamide / 0 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.10.044