Methanesulfonamide, N-[2-[ethyl(3-methylphenyl)amino]ethyl]-

Base Information

• Chemical Name: Methanesulfonamide, N-[2-[ethyl(3-methylphenyl)amino]ethyl]-
• CAS No.: 37717-68-3
• Molecular Formula: C12H20 N2 O2 S
• Molecular Weight: 256.369
• European Community (EC) Number: 253-639-4
• UNII: 73B9848APD
• DSSTox Substance ID: DTXSID8042135
• Nikkaji Number: J37.707D
• Wikidata: Q27266170
• Mol file: 37717-68-3.mol

Synonyms:37717-68-3;Methanesulfonamide, N-[2-[ethyl(3-methylphenyl)amino]ethyl]-;N-[2-(N-ethyl-3-methylanilino)ethyl]methanesulfonamide;EINECS 253-639-4;UNII-73B9848APD;N-[2-[ETHYL(M-TOLUIDINO)]ETHYL]METHANESULPHONAMIDE;73B9848APD;N-(2-(Ethyl(m-toluidino))ethyl)methanesulphonamide;N-Ethyl-N-(beta-methylsulfonamidoethyl)-m-toluidine;Methanesulfonamide, N-(2-(ethyl(3-methylphenyl)amino)ethyl)-;SCHEMBL7897227;DTXSID8042135;AKOS034249937;FT-0738959;W-110900;N-Ethyl-N-[2-(methylsulfonylamino)ethyl]-m-toluidine;Q27266170;Z369318196;N-{2-[ethyl(3-methylphenyl)amino]ethyl}methanesulfonamide;N-ETHYL-N-(.BETA.-METHYLSULFONAMIDOETHYL)-M-TOLUIDINE

Chemical Property of Methanesulfonamide, N-[2-[ethyl(3-methylphenyl)amino]ethyl]-

Chemical Property:

• Vapor Pressure: 1.05E-06mmHg at 25°C
• Boiling Point: 403°Cat760mmHg
• Flash Point: 197.5°C
• PSA: 57.79000
• Density: 1.149g/cm³
• LogP: 2.84220
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 256.12454906
• Heavy Atom Count: 17
• Complexity: 311

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CCNS(=O)(=O)C)C1=CC=CC(=C1)C

Technology Process of Methanesulfonamide, N-[2-[ethyl(3-methylphenyl)amino]ethyl]-

There total 5 articles about Methanesulfonamide, N-[2-[ethyl(3-methylphenyl)amino]ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-ethyl-N-(2-hydroxyethyl)-3-methylaniline (91-88-3) → N-[2-(N-ethyl-m-toluidino)-ethyl]-methanesulfonamide (37717-68-3)

Guidance literature:

Multi-step reaction with 4 steps

1: POCl₃

2: 180 °C

3: aqueous HBr

4: aqueous NaOH

With sodium hydroxide; hydrogen bromide; trichlorophosphate;

DOI:10.1021/ja01151a037

Reference yield:

N-[2-(N-ethyl-m-toluidino)-ethyl]-phthalimide (2498-02-4) → N-[2-(N-ethyl-m-toluidino)-ethyl]-methanesulfonamide (37717-68-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous HBr

2: aqueous NaOH

With sodium hydroxide; hydrogen bromide;

DOI:10.1021/ja01151a037

Reference yield:

N-ethyl-m-toulidine (102-27-2) → N-[2-(N-ethyl-m-toluidino)-ethyl]-methanesulfonamide (37717-68-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 130 - 135 °C

2: POCl₃

3: 180 °C

4: aqueous HBr

5: aqueous NaOH

With sodium hydroxide; hydrogen bromide; trichlorophosphate;

DOI:10.1021/ja01151a037

upstream raw materials:

N₁-ethyl-N₁-(3-methylphenyl)-1,2-ethanediamine

methanesulfonyl chloride

N-ethyl-N-(2-hydroxyethyl)-3-methylaniline

N-[2-(N-ethyl-m-toluidino)-ethyl]-phthalimide