Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(2-cyanoethoxy)methyl]- N-(phenoxyacetyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Base Information

Chemical Name:Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(2-cyanoethoxy)methyl]- N-(phenoxyacetyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
CAS No.:863408-48-4
Molecular Formula:C52H59N8O11P
Molecular Weight:1003.06
Hs Code.:

Guanosine,
5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(2-cyanoethoxy)methyl]-
N-(phenoxyacetyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

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Chemical Property of Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(2-cyanoethoxy)methyl]- N-(phenoxyacetyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

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Technology Process of Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(2-cyanoethoxy)methyl]- N-(phenoxyacetyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

There total 4 articles about Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(2-cyanoethoxy)methyl]- N-(phenoxyacetyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 863408-43-9
N²-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-cyanoethoxymethyl)guanosine

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 863408-48-4
N²-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-cyanoethoxymethyl)guanosine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ol051151f

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 863408-48-4
N²-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-cyanoethoxymethyl)guanosine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine

2: 51 percent / N,N-diisopropylethylamine; dibutyltin dichloride / 1,2-dichloro-ethane / 1 h / 80 °C

3: 80 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 1 h / 20 °C

With pyridine; dibutyltin chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol051151f

Reference yield:

: 121058-81-9
5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N₂-phenoxyacetylguanosine

: 863408-48-4
N²-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-cyanoethoxymethyl)guanosine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / N,N-diisopropylethylamine; dibutyltin dichloride / 1,2-dichloro-ethane / 1 h / 80 °C

2: 80 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 1 h / 20 °C

With dibutyltin chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol051151f