3-Azabicyclo[3.1.0]hexane, 1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-[3-[[4-methyl-5-(4-methyl-5-oxazol yl)-4H-1,2,4-triazol-3-yl]thio]propyl]-

Base Information

• Chemical Name: 3-Azabicyclo[3.1.0]hexane, 1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-[3-[[4-methyl-5-(4-methyl-5-oxazol yl)-4H-1,2,4-triazol-3-yl]thio]propyl]-
• CAS No.: 863680-45-9
• Molecular Formula: C22H23F4N5OS
• Molecular Weight: 481.51000

Synonyms:

Chemical Property of 3-Azabicyclo[3.1.0]hexane, 1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-[3-[[4-methyl-5-(4-methyl-5-oxazol yl)-4H-1,2,4-triazol-3-yl]thio]propyl]-

Chemical Property:

• Boiling Point: 593.6±60.0 °C(Predicted)
• PSA: 85.28000
• Density: 1.49±0.1 g/cm3(Predicted)
• LogP: 4.63000

Purity/Quality:

97% ^*data from raw suppliers

GSK598809 99.73% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Azabicyclo[3.1.0]hexane, 1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-[3-[[4-methyl-5-(4-methyl-5-oxazol yl)-4H-1,2,4-triazol-3-yl]thio]propyl]-

There total 1 articles about 3-Azabicyclo[3.1.0]hexane, 1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-[3-[[4-methyl-5-(4-methyl-5-oxazol yl)-4H-1,2,4-triazol-3-yl]thio]propyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[(3-chloropropyl)sulfanyl]-4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazole (863679-31-6) + (1R,5S/1S,5R)-1-[2-fluoro-4-(trifluoromethyl)pheny|]-3-azabicyclo-[3.1.0]hexane (863679-53-2) → GSK598809 (863680-45-9)

Guidance literature:

With sodium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 60 ℃; for 24h;

Reference yield:

GSK598809 (863680-45-9) → GSK 598809A (863680-46-0) + (1R,5S)-1-[2-fluoro-4-(trifluoromethyl)pheny|]-3-(3-{[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio}propyl)-3-azabicyclo-[3.1.0]hexane

Guidance literature:

Resolution of racemate;

upstream raw materials:

3-[(3-chloropropyl)sulfanyl]-4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazole

(1R,5S/1S,5R)-1-[2-fluoro-4-(trifluoromethyl)pheny|]-3-azabicyclo-[3.1.0]hexane

Downstream raw materials:

GSK 598809A

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