Technology Process of ethyl 4-[4-(2-methoxyphenyl)piperazin-1-yl]-3,4-dihydro-2H-chromene-6-carboxylate
There total 7 articles about ethyl 4-[4-(2-methoxyphenyl)piperazin-1-yl]-3,4-dihydro-2H-chromene-6-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 38 percent / potassium hydroxide / H2O / 4 h / 80 - 90 °C
2: 60 percent / phosphorous pentoxide / benzene / 10 h / Heating
3: 70 percent / hydroxylamine hydrochloride, potassium carbonate / ethanol / 6 h / Heating
4: 80 percent / hydrogene / Raney nickel / ethanol
5: 68.8 percent / ethanol / 2 h / Ambient temperature
6: 86 percent / thionyl chloride / CHCl3 / 1.) 0 deg C, 2.) room temperature, 24 h
7: sodium iodide, sodium carbonate / butan-1-ol
With
phosphorus pentaoxide; potassium hydroxide; thionyl chloride; hydroxylamine hydrochloride; hydrogen; sodium carbonate; potassium carbonate; sodium iodide;
nickel;
In
ethanol; chloroform; water; butan-1-ol; benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 70 percent / hydroxylamine hydrochloride, potassium carbonate / ethanol / 6 h / Heating
2: 80 percent / hydrogene / Raney nickel / ethanol
3: 68.8 percent / ethanol / 2 h / Ambient temperature
4: 86 percent / thionyl chloride / CHCl3 / 1.) 0 deg C, 2.) room temperature, 24 h
5: sodium iodide, sodium carbonate / butan-1-ol
With
thionyl chloride; hydroxylamine hydrochloride; hydrogen; sodium carbonate; potassium carbonate; sodium iodide;
nickel;
In
ethanol; chloroform; butan-1-ol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80 percent / hydrogene / Raney nickel / ethanol
2: 68.8 percent / ethanol / 2 h / Ambient temperature
3: 86 percent / thionyl chloride / CHCl3 / 1.) 0 deg C, 2.) room temperature, 24 h
4: sodium iodide, sodium carbonate / butan-1-ol
With
thionyl chloride; hydrogen; sodium carbonate; sodium iodide;
nickel;
In
ethanol; chloroform; butan-1-ol;