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Technology Process of 4(3H)-Pyrimidinone, 2-(((2S)-2-amino-3-phenylpropyl)amino)-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-

4(3H)-Pyrimidinone, 2-(((2S)-2-amino-3-phenylpropyl)amino)-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-

Base Information
  • Chemical Name:4(3H)-Pyrimidinone, 2-(((2S)-2-amino-3-phenylpropyl)amino)-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-
  • CAS No.:864249-60-5
  • Molecular Formula:C29H27N5O
  • Molecular Weight:461.566
  • Hs Code.:
  • European Community (EC) Number:804-485-7
  • UNII:PGR0H531I4
  • DSSTox Substance ID:DTXSID201347617
  • Wikidata:Q27286549
  • Pharos Ligand ID:4VZQ6AWZU6PC
  • ChEMBL ID:CHEMBL585902
  • Mol file:864249-60-5.mol
4(3H)-Pyrimidinone, 2-(((2S)-2-amino-3-phenylpropyl)amino)-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-

Synonyms:AMG-548;864249-60-5;AMG 548;UNII-PGR0H531I4;CHEMBL585902;PGR0H531I4;4(3H)-Pyrimidinone, 2-(((2S)-2-amino-3-phenylpropyl)amino)-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-;2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone;D02MVG;SCHEMBL433425;RQVKVJIRFKVPBF-VWLOTQADSA-N;DTXSID201347617;P38 MAP kinase inhibitor, Amgen;BDBM50303597;AKOS024457873;AT33611;NCGC00370979-01;NCGC00370979-02;HY-108642;CS-0029376;Q27286549;(S)-2-(2-amino-3-phenylpropylamino)-3-methyl-5-(naphthalen-2-yl)-6-(pyridin-4-yl)pyrimidin-4(3H)-one;2-[[(2S)-2-amino-3-phenylpropyl]amino]-3-methyl-5-naphthalen-2-yl-6-pyridin-4-ylpyrimidin-4-one;2-{[(2S)-2-Amino-3-phenylpropyl]amino}-3-methyl-5-(2-naphthyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone

Suppliers and Price of 4(3H)-Pyrimidinone, 2-(((2S)-2-amino-3-phenylpropyl)amino)-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • AMG 548
  • 10mg
  • $ 593.00
  • Usbiological
  • AMG 548
  • 10mg
  • $ 545.00
  • TRC
  • AMG548
  • 100mg
  • $ 1400.00
  • TRC
  • AMG548
  • 50mg
  • $ 795.00
  • TRC
  • AMG548
  • 10mg
  • $ 175.00
  • Tocris
  • AMG548 ≥98%(HPLC)
  • 10
  • $ 289.00
  • Sigma-Aldrich
  • AMG-548 dihydrochloride ≥98% (HPLC)
  • 25mg
  • $ 455.00
  • Sigma-Aldrich
  • AMG-548 dihydrochloride ≥98% (HPLC)
  • 5mg
  • $ 109.00
  • DC Chemicals
  • AMG-548 >98%
  • 1 g
  • $ 3600.00
  • ChemScene
  • AMG-548 dihydrochloride ≥98.0%
  • 5mg
  • $ 270.00
Total 3 raw suppliers
Chemical Property of 4(3H)-Pyrimidinone, 2-(((2S)-2-amino-3-phenylpropyl)amino)-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-
Chemical Property:
  • PSA：85.83000 
  • LogP:5.41770 
  • Storage Temp.:?20°C 
  • Solubility.:DMSO: soluble5mg/mL, clear (warmed) 
  • XLogP3:3.8
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:7
  • Exact Mass:461.22156050
  • Heavy Atom Count:35
  • Complexity:795
Purity/Quality:

98% *data from raw suppliers

AMG 548 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes:T 
  • Statements: 25-36/37/38 
  • Safety Statements: 26-45 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CN1C(=O)C(=C(N=C1NCC(CC2=CC=CC=C2)N)C3=CC=NC=C3)C4=CC5=CC=CC=C5C=C4
  • Isomeric SMILES:CN1C(=O)C(=C(N=C1NC[C@H](CC2=CC=CC=C2)N)C3=CC=NC=C3)C4=CC5=CC=CC=C5C=C4
  • Uses AMG 548 is a selective and efficacious p38 mitogen-activated protein (MAP) kinase inhibitor, which are a class of inhibitors that are investigated towards treating inflammatory diseases.
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