1H-Pyrazolo[4,3-b]pyridine-1-carboxylic acid, 3-(2-chlorophenyl)-6-(2,4-difluorophenoxy)-4,5-dihydro-4-methyl-5-oxo-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1H-Pyrazolo[4,3-b]pyridine-1-carboxylic acid, 3-(2-chlorophenyl)-6-(2,4-difluorophenoxy)-4,5-dihydro-4-methyl-5-oxo-, 1,1-dimethylethyl ester
• CAS No.: 864300-96-9
• Molecular Formula: C24H20ClF2N3O4
• Molecular Weight: 487.89

Synonyms:

Chemical Property of 1H-Pyrazolo[4,3-b]pyridine-1-carboxylic acid, 3-(2-chlorophenyl)-6-(2,4-difluorophenoxy)-4,5-dihydro-4-methyl-5-oxo-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of 1H-Pyrazolo[4,3-b]pyridine-1-carboxylic acid, 3-(2-chlorophenyl)-6-(2,4-difluorophenoxy)-4,5-dihydro-4-methyl-5-oxo-, 1,1-dimethylethyl ester

There total 1 articles about 1H-Pyrazolo[4,3-b]pyridine-1-carboxylic acid, 3-(2-chlorophenyl)-6-(2,4-difluorophenoxy)-4,5-dihydro-4-methyl-5-oxo-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(2,4-difluorophenoxy)-3-iodo-4-methyl-5-oxo-4,5-dihydro-pyrazolo[4,3-b]pyridine-1-carboxylic acid tert-butyl ester (864300-95-8) + 2-Chlorobenzeneboronic acid (3900-89-8) → 3-(2-chlorophenyl)-6-(2,4-difluorophenoxy)-4-methyl-5-oxo-4,5-dihydro-pyrazolo[4,3-b]pyridine-1-carboxylic acid tert-butyl ester (864300-96-9)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; benzene; for 2h; Heating / reflux;

Reference yield:

3-(2-chlorophenyl)-6-(2,4-difluorophenoxy)-4-methyl-5-oxo-4,5-dihydro-pyrazolo[4,3-b]pyridine-1-carboxylic acid tert-butyl ester (864300-96-9) → 3-(2-chloro-phenyl)-6-(2,4-difluoro-phenoxy)-4-methyl-1,4-dihydro-pyrazolo[4,3-b]pyridin-5-one (864298-79-3)

Guidance literature:

With methanol; sodium methylate; at 20 ℃; for 1h;

upstream raw materials:

6-(2,4-difluorophenoxy)-3-iodo-4-methyl-5-oxo-4,5-dihydro-pyrazolo[4,3-b]pyridine-1-carboxylic acid tert-butyl ester

2-Chlorobenzeneboronic acid

Downstream raw materials:

3-(2-chloro-phenyl)-6-(2,4-difluoro-phenoxy)-4-methyl-1,4-dihydro-pyrazolo[4,3-b]pyridin-5-one

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