(3R,4R)-1-Benzylpyrrolidine-3,4-diol

Base Information

Chemical Name:(3R,4R)-1-Benzylpyrrolidine-3,4-diol
CAS No.:163439-82-5
Molecular Formula:C11H15 N O2
Molecular Weight:193.246
Hs Code.:29339900
European Community (EC) Number:634-924-6
DSSTox Substance ID:DTXSID20427376
Nikkaji Number:J654.286G
Wikidata:Q72442925
ChEMBL ID:CHEMBL2335509
Mol file:163439-82-5.mol

Synonyms:163439-82-5;(3R,4R)-1-Benzylpyrrolidine-3,4-diol;(3R,4R)-(-)-1-Benzyl-3,4-pyrrolidindiol;3,4-Pyrrolidinediol, 1-(phenylmethyl)-, (3R,4R)-;(3R,4R)-(-)-1-Benzyl-3,4-pyrrolidinediol;rel-(3R,4R)-1-Benzylpyrrolidine-3,4-diol;330152-66-4;76784-33-3;MFCD01073894;SCHEMBL71063;CHEMBL2335509;DTXSID20427376;QJRIUWQPJVPYSO-GHMZBOCLSA-N;AMY37472;AKOS005264658;AKOS015994967;CS-W015769;FS-2183;trans-3,4-dihydroxy-N-benzylpyrrolidine;AC-22436;BP-12366;(3R)-1-Benzylpyrrolidine-3beta,4alpha-diol;(3R,4R)-1-benzyl-3,4-dihydroxy-pyrrolidine;J-501253;J-800407;(3R,4R)-(-)-1-Benzyl-3,4-pyrrolidinediol, >=97.0% (sum of enantiomers, HPLC)

Suppliers and Price of (3R,4R)-1-Benzylpyrrolidine-3,4-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3R,4R)-1-benzylpyrrolidine-3,4-diol
500mg
$ 130.00

SynQuest Laboratories
(3R,4R)-1-Benzylpyrrolidine-3,4-diol
1 g
$ 525.00

SynQuest Laboratories
(3R,4R)-1-Benzylpyrrolidine-3,4-diol
250 mg
$ 175.00

Sigma-Aldrich
(3R,4R)-(?)-1-Benzyl-3,4-pyrrolidinediol ≥97.0% (sum of enantiomers, HPLC)
500mg
$ 114.00

Oakwood
(3R,4R)-(-)-1-Benzyl-3,4-pyrrolidindiol 97%
1g
$ 80.00

Matrix Scientific
(3R,4R)-1-Benzylpyrrolidine-3,4-diol 97.0%
1g
$ 155.00

Frontier Specialty Chemicals
(3R,4R)-(-)-1-Benzyl-3,4-pyrrolidindiol 97%
1g
$ 241.00

Frontier Specialty Chemicals
(3R,4R)-(-)-1-Benzyl-3,4-pyrrolidindiol 97%
250mg
$ 82.00

Crysdot
(3R,4R)-1-Benzylpyrrolidine-3,4-diol 98%
10g
$ 251.00

Crysdot
(3R,4R)-1-Benzylpyrrolidine-3,4-diol 98%
25g
$ 616.00

Total 65 raw suppliers

Chemical Property of (3R,4R)-1-Benzylpyrrolidine-3,4-diol

Chemical Property:

Appearance/Colour:off-white to light brown powder
Vapor Pressure:1.08E-05mmHg at 25°C
Melting Point:94-100 °C
Refractive Index:1.633
Boiling Point:356.2 °C at 760 mmHg
PKA:13.99±0.40(Predicted)
Flash Point:195.1 °C
PSA：43.70000
Density:1.27 g/cm³
LogP:0.16190
Storage Temp.:Inert atmosphere,Room Temperature
XLogP3:0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:193.110278721
Heavy Atom Count:14
Complexity:170

Purity/Quality:

≥99% ^*data from raw suppliers

(3R,4R)-1-benzylpyrrolidine-3,4-diol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1C(C(CN1CC2=CC=CC=C2)O)O
Isomeric SMILES:C1[C@H]([C@@H](CN1CC2=CC=CC=C2)O)O

Technology Process of (3R,4R)-1-Benzylpyrrolidine-3,4-diol

There total 10 articles about (3R,4R)-1-Benzylpyrrolidine-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 187032-53-7
(3S,4S)-1-N-benzyl-3,4-dihydroxypyrrolidine-2,6-dione

: 163439-82-5,330152-66-4
(3R,4R)-1-benzyl-3,4-pyrrolidinediol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 12h; Heating;
DOI:10.1016/j.tetlet.2005.10.005

Reference yield: 88.5%

: 75172-31-5
(3R,4R)-1-benzyl-3,4-dihydroxypyrrolidine-2,5-dione

: 163439-82-5,330152-66-4
(3R,4R)-1-benzyl-3,4-pyrrolidinediol

Guidance literature:: With borane-THF; In tetrahydrofuran; at 70 ℃; for 3h;
DOI:10.1016/j.bmcl.2017.04.078

Reference yield: 46.0%

: 50623-73-9,68138-99-8
(2R,3R)-2,3-dihydroxy-4-{[(4-methylphenyl)sulfonyl]oxy}butyl 4-methyl-1-benzenesulfonate

: 100-46-9
benzylamine

: 163439-82-5,330152-66-4
(3R,4R)-1-benzyl-3,4-pyrrolidinediol

Guidance literature:: (2R,3R)-2,3-dihydroxy-4-{[(4-methylphenyl)sulfonyl]oxy}butyl 4-methyl-1-benzenesulfonate; benzylamine; In 1,4-dioxane; for 96h; Heating / reflux;

With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃;