(5-Phenyl-4,5-dihydro-[1,2,4]triazolo[1,5-a]quinoxalin-2-yl)methanol

Base Information

Chemical Name:(5-Phenyl-4,5-dihydro-[1,2,4]triazolo[1,5-a]quinoxalin-2-yl)methanol
CAS No.:86514-33-2
Molecular Formula:C16H14N4O
Molecular Weight:278.313
Hs Code.:
DSSTox Substance ID:DTXSID00542798
Wikidata:Q82419564

Synonyms:86514-33-2;(5-Phenyl-4,5-dihydro-[1,2,4]triazolo[1,5-a]quinoxalin-2-yl)methanol;SCHEMBL11004115;DTXSID00542798;(5-Phenyl-4,5-dihydro[1,2,4]triazolo[1,5-a]quinoxalin-2-yl)methanol

Suppliers and Price of (5-Phenyl-4,5-dihydro-[1,2,4]triazolo[1,5-a]quinoxalin-2-yl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (5-Phenyl-4,5-dihydro-[1,2,4]triazolo[1,5-a]quinoxalin-2-yl)methanol

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:278.11676108
Heavy Atom Count:21
Complexity:360

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2=NC(=NN2C3=CC=CC=C3N1C4=CC=CC=C4)CO

Technology Process of (5-Phenyl-4,5-dihydro-[1,2,4]triazolo[1,5-a]quinoxalin-2-yl)methanol

There total 8 articles about (5-Phenyl-4,5-dihydro-[1,2,4]triazolo[1,5-a]quinoxalin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 86514-42-3
methyl 4,5-dihydro-5-phenyl<1,2,4>triazolo<1,5-a>quinoxaline-2-carboxylate

: 86514-33-2
4,5-dihydro-5-phenyl<1,2,4>triazolo<1,5-a>quinoxaline-2-methanol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 25 ℃; for 2h;
DOI:10.1002/hlca.19870700817

Reference yield:

: 119-75-5
2-nitro-N-phenylaniline

: 86514-33-2
4,5-dihydro-5-phenyl<1,2,4>triazolo<1,5-a>quinoxaline-2-methanol

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1.) DMF, room temp., 3 h; 2.) pH=8, room temp., 30 min

2: 93 percent / hydrogen / Raney-Ni / ethanol / 29 h / 20 °C

3: 1.) cc. HCl; 2.) aq. K₂CO₃ / 1.) AcOH, 2 deg C, 15 min; 2.) pH=6, 5 deg C, 2 h

4: 1.) aq. NaOH; 2.) aq. HCl / 1.) MeOH, room temp., 90 min; 2.) 0 deg C, 3 h, pH=2

5: 96 percent / cc. HBr / 22 h / 100 °C

6: 84 percent / HCl / 4 h / 0 °C

7: 85 percent / NaBH₄ / methanol; tetrahydrofuran / 2 h / 25 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; hydrogen bromide; hydrogen; sodium hydride; potassium carbonate; nickel; In tetrahydrofuran; methanol; ethanol;
DOI:10.1002/hlca.19870700817

Reference yield:

: 86514-36-5
ethyl 2-nitro-N-phenylbenzene-1-carbamate

: 86514-33-2
4,5-dihydro-5-phenyl<1,2,4>triazolo<1,5-a>quinoxaline-2-methanol

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / hydrogen / Raney-Ni / ethanol / 29 h / 20 °C

2: 1.) cc. HCl; 2.) aq. K₂CO₃ / 1.) AcOH, 2 deg C, 15 min; 2.) pH=6, 5 deg C, 2 h

3: 1.) aq. NaOH; 2.) aq. HCl / 1.) MeOH, room temp., 90 min; 2.) 0 deg C, 3 h, pH=2

4: 96 percent / cc. HBr / 22 h / 100 °C

5: 84 percent / HCl / 4 h / 0 °C

6: 85 percent / NaBH₄ / methanol; tetrahydrofuran / 2 h / 25 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; hydrogen bromide; hydrogen; potassium carbonate; nickel; In tetrahydrofuran; methanol; ethanol;
DOI:10.1002/hlca.19870700817