5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine

Base Information

• Chemical Name: 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
• CAS No.: 865362-74-9
• Molecular Formula: C₁₈H₁₃N₇
• Molecular Weight: 327.348
• Hs Code.: 29339900
• Mol file: 865362-74-9.mol

Synonyms:

Chemical Property of 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine

Chemical Property:

• Melting Point: 267 °C
• PKA: 7.19±0.50(Predicted)
• PSA: 98.51000
• Density: 1.55±0.1 g/cm3(Predicted)
• LogP: 2.84690
• Storage Temp.: Store at +4°C
• Solubility.: DMSO: ≥10mg/mL

Purity/Quality:

98%,99%, ^*data from raw suppliers

FR 180204 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-20
• Safety Statements: 20/21

MSDS Files:

SDS file from LookChem

Useful:

• Uses: FR180204 has been used as ERK inhibitor:to block extracellular-signal-regulated kinase (ERK) in order to validate whether homeobox B7 (HOXB7) regulates the migration and proliferation process via AKT/mitogen-activated protein kinases (MAPK) signalingof extracellular-signal-regulated kinase (ERK) to study the effects of signaling pathway inhibitors on differentiation and cell traction stress to determine if phosphorylation of this signaling protein is essential for mesenchymal stromal cell (MSC) derived therapeutic efficacy

Technology Process of 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine

There total 1 articles about 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

C18H10ClN5 (1196794-13-4) → FR180204 (865362-74-9)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; Reflux;

DOI:10.1021/jo901835m

upstream raw materials:

C₁₈H₁₀ClN₅

Refernces