Chemical Property of Trelagliptin
Chemical Property:
- Appearance/Colour:White to off-white solid
- Boiling Point:519.0±60.0 °C(Predicted)
- PKA:9.88±0.20(Predicted)
- PSA：97.05000
- Density:1.38±0.1 g/cm3(Predicted)
- LogP:1.29888
- Solubility.:≥11.6 mg/mL in DMSO; ≥3.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥93.8 mg/mL in H2O
- XLogP3:0.7
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:3
- Exact Mass:357.16010306
- Heavy Atom Count:26
- Complexity:657
- Purity/Quality:
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99%, *data from raw suppliers
(S)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CN1C(=O)C=C(N(C1=O)CC2=C(C=CC(=C2)F)C#N)N3CCCC(C3)N
- Isomeric SMILES:CN1C(=O)C=C(N(C1=O)CC2=C(C=CC(=C2)F)C#N)N3CCC[C@H](C3)N
- Recent ClinicalTrials:A Phase 1, Bioequivalence Study of SYR-472 25mg and 50mg Tablets
- Recent EU Clinical Trials:A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, Multicenter
- Recent NIPH Clinical Trials:Specified Drug-Use Survey of Trelagliptin Tablets 'Survey on Long-term Use in Type 2 Diabetes Mellitus Patients with severe renal impairment or end-stage renal disease'
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Uses
Trelagliptin is a highly selective, long-acting dipeptidyl peptidase IV (DPP-4) inhibitor. This inhibitor provides sustained reduction of plasma DPP-4 activity and lowering of blood glucose in animal models of diabetes.
