Technology Process of 2H-Pyran,
2-[[2,6-dimethyl-8-(phenylmethoxy)-2,6-octadienyl]oxy]tetrahydro-, (Z,Z)-
There total 13 articles about 2H-Pyran,
2-[[2,6-dimethyl-8-(phenylmethoxy)-2,6-octadienyl]oxy]tetrahydro-, (Z,Z)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
[((4Z)-6-(benzyloxy)-4-methylhex-4-enyl)]triphenylphosphonium iodide;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
1-hydroxypropan-2-one tetrahydropyran ether;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
stereoselective reaction;
DOI:10.1002/ejoc.201301089
- Guidance literature:
-
[((4Z)-6-(benzyloxy)-4-methylhex-4-enyl)]triphenylphosphonium iodide;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -12 ℃;
for 0.1h;
hydroxyacetone 1-(tetrahydro-2H-pyran-2-yl) ether;
In
tetrahydrofuran; hexane;
at -12 - 20 ℃;
DOI:10.1002/chem.201301074
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 2 h / 75 °C
1.2: 1 h / Reflux
2.1: water; N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 °C
3.1: potassium carbonate / methanol / 1 h / -5 °C
4.1: periodic acid; di-isopropyl ether / water / 14 h / -10 - 20 °C
5.1: sodium tetrahydroborate / ethanol / 1.5 h / -10 - 20 °C
6.1: pyridine / 8 h / -5 °C
7.1: sodium iodide / acetone / 20 °C
8.1: toluene / 117 h / Reflux
9.1: n-butyllithium / tetrahydrofuran; hexane / 0.1 h / -12 °C
9.2: -12 - 20 °C
With
pyridine; sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; di-isopropyl ether; water; sodium hydride; potassium carbonate; periodic acid; sodium iodide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; hexane; water; acetone; toluene; mineral oil;
DOI:10.1002/chem.201301074
