1H-Pyrrole-3-acetic acid, 1-(phenylsulfonyl)-

Base Information

• Chemical Name: 1H-Pyrrole-3-acetic acid, 1-(phenylsulfonyl)-
• CAS No.: 86688-98-4
• Molecular Formula: C12H11NO4S
• Molecular Weight: 265.29
• Mol file: 86688-98-4.mol

Synonyms:(1-Benzenesulfonyl-1H-pyrrol-3-yl)-acetic acid;(1-Benzenesulfonyl-1H- pyrrol-3-yl) acetic acid;1-(benzenesulphonyl)-3-pyrrolylacetic acid;1-phenylsulfonylpyrrrol-3-ylacetic acid;1-phenylsulphonylpyrrol-3-ylacetic acid;

Chemical Property of 1H-Pyrrole-3-acetic acid, 1-(phenylsulfonyl)-

Chemical Property:

• Melting Point: 99-100 °C
• Boiling Point: 502.0±42.0 °C(Predicted)
• PSA: 84.75000
• Density: 1.36±0.1 g/cm3(Predicted)
• LogP: 2.43300

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrole-3-acetic acid, 1-(phenylsulfonyl)-

There total 1 articles about 1H-Pyrrole-3-acetic acid, 1-(phenylsulfonyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(Phenylsulfonyl)-3-(carbomethoxymethyl)pyrrole (86688-97-3) → 1-(Phenylsulfonyl)-3-pyrrolylacetic acid (86688-98-4)

Guidance literature:

1-(Phenylsulfonyl)-3-(carbomethoxymethyl)pyrrole; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 0.75h;

With hydrogenchloride; In water;

Reference yield: 58.0%

methyl 2,3-difluorobenzoate (18355-74-3) + 1-(Phenylsulfonyl)-3-pyrrolylacetic acid (86688-98-4) → 2-(1-benzenesulfonyl-1H-pyrrol-3-yl)-1-(2,3-difluoro-phenyl)-ethanone (845868-03-3)

Guidance literature:

1-(Phenylsulfonyl)-3-pyrrolylacetic acid; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 0 ℃; for 2h;

methyl 2,3-difluorobenzoate; In tetrahydrofuran; at -78 - 20 ℃; for 14h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield: 43.0%

1-(Phenylsulfonyl)-3-pyrrolylacetic acid (86688-98-4) + acetic anhydride (108-24-7) → 7-Methyl-1-phenylsulphonylpyrano<3,4-b>pyrrol-5(1H)-one (130103-45-6)

Guidance literature:

With boron trifluoride diethyl etherate; In diethyl ether; for 6h; Ambient temperature;

DOI:10.1016/S0040-4020(01)90360-6

upstream raw materials:

1-(Phenylsulfonyl)-3-(carbomethoxymethyl)pyrrole

Downstream raw materials:

7-pentyl-1-phenylsulfonylpyrano<3,4-b>pyrrol-5(1H)-one

7-(pent-1-yn-5-yl)-1-phenylsulfonylpyrano<3,4-b>pyrrol-5(1H)-one

7-Methyl-1-phenylsulphonylpyrano<3,4-b>pyrrol-5(1H)-one

7-isopropyl-1-phenylsulfonylpyrano<3,4-b>pyrrol-5(1H)-one