(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine

Base Information

• Chemical Name: (R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine
• CAS No.: 867256-73-3
• Molecular Formula: C10H20N2
• Molecular Weight: 168.27900
• Hs Code.: 2933990090
• Mol file: 867256-73-3.mol

Synonyms:LogP

Chemical Property of (R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine

Chemical Property:

• Vapor Pressure: 0.0749mmHg at 25°C
• Refractive Index: 1.486
• Boiling Point: 228.1°C at 760 mmHg
• Flash Point: 80.7°C
• PSA: 15.27000
• Density: 0.944g/cm3
• LogP: 1.48940
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(R)-2-Methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine

There total 5 articles about (R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2(S)-(2(R)-methyl-pyrrolidin-1-yl)-pyrrolidin-2-yl-methanone → (2R)-2-methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine (867256-73-3,760993-63-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 - 40 ℃; for 18.75h;

Reference yield:

((R)-2-methyl-pyrrolidin-1-yl)-pyrrolidin-2-yl-methanone → (2R)-2-methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine (867256-73-3,760993-63-3)

Guidance literature:

((R)-2-methyl-pyrrolidin-1-yl)-pyrrolidin-2-yl-methanone; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 - 40 ℃; for 18.75h; Inert atmosphere;

With water; sodium hydroxide; In tetrahydrofuran; at 15 ℃; Cooling with ice bath;

Reference yield:

(2(R)-methyl-pyrrolidin-1-yl)-pyrrolidin-2-yl-methanone (1379448-37-9) → (2R)-2-methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine (867256-73-3,760993-63-3)

Guidance literature:

(2(R)-methyl-pyrrolidin-1-yl)-pyrrolidin-2-yl-methanone; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 - 40 ℃; for 18.75h;

With sodium hydroxide; water; at 0 - 15 ℃;

upstream raw materials:

(2(R)-methyl-pyrrolidin-1-yl)-pyrrolidin-2-yl-methanone

Downstream raw materials:

[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone

Refernces

• 1、 -. "HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES". Page/Page column 36; 37. . Retrieved 2010/03/31.
• 2、 -. "HISTAMINE H3 RECEPTOR INHIBITORS, PREPARATION AND THERAPEUTIC USES". Page/Page column 34. . Retrieved 2008/06/13.