3-Pyrrolidinone, 5-(3-butenyl)-1-[(4-methylphenyl)sulfonyl]-, (5R)-

Base Information

Chemical Name:3-Pyrrolidinone, 5-(3-butenyl)-1-[(4-methylphenyl)sulfonyl]-, (5R)-
CAS No.:870246-63-2
Molecular Formula:C15H19NO3S
Molecular Weight:293.387
Hs Code.:

Synonyms:

Suppliers and Price of 3-Pyrrolidinone, 5-(3-butenyl)-1-[(4-methylphenyl)sulfonyl]-, (5R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 3-Pyrrolidinone, 5-(3-butenyl)-1-[(4-methylphenyl)sulfonyl]-, (5R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-Pyrrolidinone, 5-(3-butenyl)-1-[(4-methylphenyl)sulfonyl]-, (5R)-

There total 11 articles about 3-Pyrrolidinone, 5-(3-butenyl)-1-[(4-methylphenyl)sulfonyl]-, (5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 870246-63-2
(2R)-2-(but-3-en-1-yl)-1-(4-methylphenyl)sulfonyl-2-pyrrolidin-4-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: 2.93 g / triethylamine / CH₂Cl₂ / 10 h / 20 °C

2.1: 3.93 g / imidazole / dimethylformamide / 2 h / 20 °C

3.1: 3.47 g / NaBH₄; LiCl; MeOH / 12 h / 20 °C

4.1: 950 mg / oxalyl chloride; triethylamine; DMSO / CH₂Cl₂ / -78 - 20 °C

5.1: 1.06 g / CH₂Cl₂ / 5 h / 20 °C

6.1: 99 percent / H₂ / Pd/C / methanol / 10 h / 20 °C

7.1: 94 percent / LiAlH₄ / tetrahydrofuran / 3 h / 20 °C

8.1: 88 percent / pyridinium chlorochromate; Celite / CH₂Cl₂ / 15 h / 20 °C

9.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

9.2: 85 percent / tetrahydrofuran; hexane / 8 h / -30 °C

10.1: TBAF / tetrahydrofuran / 1 h / 20 °C

10.2: 89 percent / pyridinium chlorochromate; Celite / CH₂Cl₂ / 10 h / 20 °C

With 1H-imidazole; methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; Celite; tetrabutyl ammonium fluoride; hydrogen; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; 4.1: Swern oxidation / 5.1: Wittig olefination / 9.2: Wittig olefination;
DOI:10.1016/j.tetlet.2005.09.024

Reference yield:

: ethyl 3-[(2S,4R)-1-(4-methylphenyl)sulfonyl-4-(t-butyldimethylsilanyloxy)pyrrolidin-2-yl]-acrylate

: 870246-63-2
(2R)-2-(but-3-en-1-yl)-1-(4-methylphenyl)sulfonyl-2-pyrrolidin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 99 percent / H₂ / Pd/C / methanol / 10 h / 20 °C

2.1: 94 percent / LiAlH₄ / tetrahydrofuran / 3 h / 20 °C

3.1: 88 percent / pyridinium chlorochromate; Celite / CH₂Cl₂ / 15 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: 85 percent / tetrahydrofuran; hexane / 8 h / -30 °C

5.1: TBAF / tetrahydrofuran / 1 h / 20 °C

5.2: 89 percent / pyridinium chlorochromate; Celite / CH₂Cl₂ / 10 h / 20 °C

With lithium aluminium tetrahydride; n-butyllithium; Celite; tetrabutyl ammonium fluoride; hydrogen; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; 4.2: Wittig olefination;
DOI:10.1016/j.tetlet.2005.09.024

Reference yield:

: 16257-57-1
methyl (2S,4R)-4-hydroxy-1-(p-tolylsulfonyl)pyrrolidine-2-carboxylate

: 870246-63-2
(2R)-2-(but-3-en-1-yl)-1-(4-methylphenyl)sulfonyl-2-pyrrolidin-4-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: 3.93 g / imidazole / dimethylformamide / 2 h / 20 °C

2.1: 3.47 g / NaBH₄; LiCl; MeOH / 12 h / 20 °C

3.1: 950 mg / oxalyl chloride; triethylamine; DMSO / CH₂Cl₂ / -78 - 20 °C

4.1: 1.06 g / CH₂Cl₂ / 5 h / 20 °C

5.1: 99 percent / H₂ / Pd/C / methanol / 10 h / 20 °C

6.1: 94 percent / LiAlH₄ / tetrahydrofuran / 3 h / 20 °C

7.1: 88 percent / pyridinium chlorochromate; Celite / CH₂Cl₂ / 15 h / 20 °C

8.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

8.2: 85 percent / tetrahydrofuran; hexane / 8 h / -30 °C

9.1: TBAF / tetrahydrofuran / 1 h / 20 °C

9.2: 89 percent / pyridinium chlorochromate; Celite / CH₂Cl₂ / 10 h / 20 °C

With 1H-imidazole; methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; Celite; tetrabutyl ammonium fluoride; hydrogen; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; 3.1: Swern oxidation / 4.1: Wittig olefination / 8.2: Wittig olefination;
DOI:10.1016/j.tetlet.2005.09.024