4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol

Base Information

• Chemical Name: 4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol
• CAS No.: 29700-22-9
• Molecular Formula: C₁₄H₁₂O₄
• Molecular Weight: 244.247
• Hs Code.: 29072990
• Mol file: 29700-22-9.mol

Synonyms:4-[(E)-2-(3,5-Dihydroxyphenyl)ethenyl]benzene-1,3-diol;

Chemical Property of 4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol

Chemical Property:

• Appearance/Colour: Yellow Solid
• Vapor Pressure: 1.37E-11mmHg at 25°C
• Melting Point: 201oC
• Refractive Index: 1.8
• Boiling Point: 523.8 °C at 760 mmHg
• PKA: 9.14±0.10(Predicted)
• Flash Point: 260.9 °C
• PSA: 80.92000
• Density: 1.468 g/cm³
• LogP: 2.67940
• Storage Temp.: 2-8°C
• Solubility.: Ethyl Acetate (Slightly), Methanol

Purity/Quality:

99% ^*data from raw suppliers

Oxyresveratrol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Description: Oxyresveratrol is an effective tyrosinase inhibitor, and has anti-tussive and anti-asthmatic, antioxidant, anti-inflammatory and analgesic effects.
• Uses: Oxyresveratrol is a natural hydroxystilbene with similar bioactivity to resveratrol. COX-1 inhibitor like resveratrol (R150000), anti-cancer agent.

Technology Process of 4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol

There total 30 articles about 4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

7-hydroxy-3-(3’,5’-dihydroxyphenyl)coumarin → oxyresveratrol (4721-07-7,29700-22-9)

Guidance literature:

With potassium hydroxide; In ethylene glycol; at 180 ℃; for 1h;

Reference yield: 76.0%

3-(3,5-dihydroxyphenyl)-7-hydroxycoumarin → oxyresveratrol (4721-07-7,29700-22-9)

Guidance literature:

With potassium hydroxide; In water; dimethyl sulfoxide; at 160 ℃; for 2h; Temperature; Reagent/catalyst;

Reference yield: 66.1%

(E)-3,5,2',4'-tetramethoxystilbene (20578-92-1,24144-92-1,143207-87-8) → oxyresveratrol (4721-07-7,29700-22-9)

Guidance literature:

With aluminum (III) chloride; In 5,5-dimethyl-1,3-cyclohexadiene; at 20 ℃; for 8h; Time;

upstream raw materials:

2,4-bis(trimethylsiloxy) benzaldehyde

(3,5-dihydroxybenzyl)triphenylphosphonium bromide

(E)-3,5,2',4'-tetramethoxystilbene

2,3′,4,5′-tetramethoxystilbene

Downstream raw materials:

5-[(E)-2-(4-hydroxy-2-methoxyphenyl)ethenyl]benzene-1,3-diol

(E)-3,5,2',4'-tetramethoxystilbene

cis-oxyresveratrol

Refernces

• 1、 -. "Preparation method of resveratrol compound". Paragraph 0061; 0062. . Retrieved 2019/07/16.
• 2、 Maafi, Mounir,Al-Qarni, Mohammed Ahmed. "Φ-order spectrophotokinetic characterisation and quantification of trans-cis oxyresveratrol reactivity, photodegradation and actinometry". . p. 64 - 71. Retrieved 2017/07/11.