(S)-([1-(2-fluoro-6-nitro-benzoyl)-phenyl-aMinocarbonyl]-propyl)-carbaMic acid tert-butyl ester

Base Information

Chemical Name:(S)-([1-(2-fluoro-6-nitro-benzoyl)-phenyl-aMinocarbonyl]-propyl)-carbaMic acid tert-butyl ester
CAS No.:870281-84-8
Molecular Formula:C22H24FN3O6
Molecular Weight:445.447
Hs Code.:
Mol file:870281-84-8.mol

Synonyms:CAL-101(N-3);(S)-tert-butyl (1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-yl)carbamate;(S)-([1-(2-fluoro-6-nitro-benzoyl)-phenyl-aminocarbonyl]-propyl)-carbamic acid tert-butyl ester;

Suppliers and Price of (S)-([1-(2-fluoro-6-nitro-benzoyl)-phenyl-aMinocarbonyl]-propyl)-carbaMic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(S)-tert-Butyl(1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-yl)carbamate 97%
5g
$ 150.00

Crysdot
(S)-tert-Butyl(1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-yl)carbamate 97%
10g
$ 200.00

Crysdot
(S)-tert-Butyl(1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-yl)carbamate 97%
25g
$ 400.00

Alichem
(S)-tert-Butyl(1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-yl)carbamate
25g
$ 392.00

Alichem
(S)-tert-Butyl(1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-yl)carbamate
10g
$ 208.00

Alichem
(S)-tert-Butyl(1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-yl)carbamate
5g
$ 157.50

Total 36 raw suppliers

Chemical Property of (S)-([1-(2-fluoro-6-nitro-benzoyl)-phenyl-aMinocarbonyl]-propyl)-carbaMic acid tert-butyl ester

Chemical Property:

Boiling Point:606.8±55.0 °C(Predicted)
PKA:10.86±0.46(Predicted)
PSA：121.53000
Density:1.291±0.06 g/cm3(Predicted)
LogP:5.12470

Purity/Quality:

97% ^*data from raw suppliers

(S)-tert-Butyl(1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-yl)carbamate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (S)-([1-(2-Fluoro-6-nitro-benzoyl)-phenyl-aminocarbonyl]-propyl)-carbamic Acid tert-Butyl Ester is an intermediate used in the preparation of anti-tumor agent Idelalisib.

Technology Process of (S)-([1-(2-fluoro-6-nitro-benzoyl)-phenyl-aMinocarbonyl]-propyl)-carbaMic acid tert-butyl ester

There total 9 articles about (S)-([1-(2-fluoro-6-nitro-benzoyl)-phenyl-aMinocarbonyl]-propyl)-carbaMic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 385-02-4
6-fluoro-2-nitrobenzoic acid

: 870281-84-8
(S)-[1-(2-fluoro-6-nitro-benzoy)phenylaminocarbonyl]propyl carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C

2.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C

2.2: 20.5 h / 5 - 30 °C

With thionyl chloride; In N,N-dimethyl-formamide;

Reference yield:

: C₁₃H₈ClFN₂O₃

: 34306-42-8
Boc-Abu

: 870281-84-8
(S)-[1-(2-fluoro-6-nitro-benzoy)phenylaminocarbonyl]propyl carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 10 - 20 ℃; for 3h;

Reference yield:

: 870281-83-7
2-fluoro-6-nitro-N-phenyl-benzamide

: 45121-22-0
Boc-D-Abu

: 870281-84-8
(S)-[1-(2-fluoro-6-nitro-benzoy)phenylaminocarbonyl]propyl carbamic acid tert-butyl ester

Guidance literature:: 2-fluoro-6-nitro-N-phenyl-benzamide; With thionyl chloride; In N,N-dimethyl-formamide; at 85 ℃; for 3h;

Boc-D-Abu; With triethylamine; In dichloromethane; at 5 - 30 ℃; for 20.5h;