Isopropyl-(tetrahydro-furan-2-ylmethyl)-amine

Base Information

• Chemical Name: Isopropyl-(tetrahydro-furan-2-ylmethyl)-amine
• CAS No.: 5064-46-0
• Molecular Formula: C8H17 N O
• Molecular Weight: 143.229
• Hs Code.: 2932190090
• NSC Number: 97525
• Mol file: 5064-46-0.mol

Synonyms:Isopropyl-(tetrahydro-furan-2-ylmethyl)-amine;5064-46-0;N-(oxolan-2-ylmethyl)propan-2-amine;N-((Tetrahydrofuran-2-yl)methyl)propan-2-amine;(oxolan-2-ylmethyl)(propan-2-yl)amine;NSC97525;SCHEMBL105301;PELLLKANMONICH-UHFFFAOYSA-N;HMS1704A18;NSC-97525;AKOS000156980;AKOS017281370;[(oxolan-2-yl)methyl](propan-2-yl)amine;CS-0235847;2-Propenamide, N-[(2-methoxyphenyl)methyl]-;EN300-162775;Tetrahydro-N-(1-methylethyl)-2-furanmethanamine;isopropyl-(tetrahydro-furan-2-ylmethyl)-amine, AldrichCPR

Chemical Property of Isopropyl-(tetrahydro-furan-2-ylmethyl)-amine

Chemical Property:

• Vapor Pressure: 0.491mmHg at 25°C
• Boiling Point: 192.3°Cat760mmHg
• PKA: 9.74±0.20(Predicted)
• Flash Point: 73.1°C
• PSA: 21.26000
• Density: 0.897g/cm³
• LogP: 1.55430
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 143.131014166
• Heavy Atom Count: 10
• Complexity: 93.3

Purity/Quality:

98%min ^*data from raw suppliers

Isopropyl-(tetrahydro-furan-2-ylmethyl)-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)NCC1CCCO1
• Uses: Isopropyl-(tetrahydro-furan-2-ylmethyl)-amine can be prepared to use as Heptatitis C virus inhibitors.

Technology Process of Isopropyl-(tetrahydro-furan-2-ylmethyl)-amine

There total 2 articles about Isopropyl-(tetrahydro-furan-2-ylmethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

TETRAHYDROFURFURYLAMINE (4795-29-3) → isopropyl-tetrahydrofurfuryl-amine (5064-46-0)

Guidance literature:

With copper oxide-chromium oxide; acetone; at 150 ℃; Hydrogenation;

Reference yield:

→ isopropyl-tetrahydrofurfuryl-amine (5064-46-0)

Guidance literature:

Furfural, 1.) Isopropylamin, 2.) katal. Hydrier.;

DOI:10.1021/jm00290a010

Reference yield: 77.0%

isopropyl-tetrahydrofurfuryl-amine (5064-46-0) + 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-methyl-1H-pyrazole-4-carboxylic acid (1127234-98-3) → 13-cyclohexyl-3-methoxy-N-[(1-methylethyl)sulfonyl]-6-[1-methyl-4-[[(1-methylethyl)[(tetrahydro-2-furanyl)methyl]amino]carbonyl]-1H-pyrazol-5-yl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide (1127237-99-3)

Guidance literature:

5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-methyl-1H-pyrazole-4-carboxylic acid; With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1.2h;

isopropyl-tetrahydrofurfuryl-amine; With dmap; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

upstream raw materials:

TETRAHYDROFURFURYLAMINE

Downstream raw materials:

13-cyclohexyl-3-methoxy-N-[(1-methylethyl)sulfonyl]-6-[1-methyl-4-[[(1-methylethyl)[(tetrahydro-2-furanyl)methyl]amino]carbonyl]-1H-pyrazol-5-yl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide