Technology Process of methyl (2R,4R)-2-(hydroxymethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)pyrrolidine-1-carboxylate
There total 6 articles about methyl (2R,4R)-2-(hydroxymethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)pyrrolidine-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
acetonitrile;
for 16h;
Heating;
DOI:10.1021/jm00128a015
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 97.3 percent / H2 / 10percent Pd/C / methanol / 16 h / 760 Torr / Ambient temperature
2: 90 percent / benzene; dimethylformamide; diethyl ether / 1.) -15 deg C, 2 h, 2.) 5 deg C, overnight
3: 89 percent / 15 N aq. NH4OH / 16 h / Heating
4: phenol, HBr, acetic acid / 16 h / 90 °C
5: 79.4 percent / potassium carbonate / acetonitrile / 16 h / Heating
With
ammonium hydroxide; hydrogen bromide; hydrogen; potassium carbonate; acetic acid; phenol;
palladium on activated charcoal;
In
methanol; diethyl ether; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jm00128a015
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / benzene; dimethylformamide; diethyl ether / 1.) -15 deg C, 2 h, 2.) 5 deg C, overnight
2: 89 percent / 15 N aq. NH4OH / 16 h / Heating
3: phenol, HBr, acetic acid / 16 h / 90 °C
4: 79.4 percent / potassium carbonate / acetonitrile / 16 h / Heating
With
ammonium hydroxide; hydrogen bromide; potassium carbonate; acetic acid; phenol;
In
diethyl ether; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jm00128a015
