Benzenesulfonamide, N-[3-[(1S,2R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(hydroxymethyl)- 3-methyl-2-(1-propynyl)-3-cyclohexen-1-yl]propyl]-4-methyl-

Base Information

Chemical Name:Benzenesulfonamide, N-[3-[(1S,2R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(hydroxymethyl)- 3-methyl-2-(1-propynyl)-3-cyclohexen-1-yl]propyl]-4-methyl-
CAS No.:870290-82-7
Molecular Formula:C27H43NO4SSi
Molecular Weight:505.794
Hs Code.:

Benzenesulfonamide,
N-[3-[(1S,2R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(hydroxymethyl)-
3-methyl-2-(1-propynyl)-3-cyclohexen-1-yl]propyl]-4-methyl-

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Chemical Property of Benzenesulfonamide, N-[3-[(1S,2R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(hydroxymethyl)- 3-methyl-2-(1-propynyl)-3-cyclohexen-1-yl]propyl]-4-methyl-

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Technology Process of Benzenesulfonamide, N-[3-[(1S,2R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(hydroxymethyl)- 3-methyl-2-(1-propynyl)-3-cyclohexen-1-yl]propyl]-4-methyl-

There total 10 articles about Benzenesulfonamide, N-[3-[(1S,2R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(hydroxymethyl)- 3-methyl-2-(1-propynyl)-3-cyclohexen-1-yl]propyl]-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 264921-02-0
tert-butyl-dimethyl-(2-methyl-1-methylene-hex-2-en-4-ynyloxy)-silane

: 870290-82-7
N-{3-[4-(tert-butyl-dimethyl-silanyloxy)-1-hydroxymethyl-3-methyl-2-prop-1-ynyl-cyclohex-3-enyl]-propyl}-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: AgSbF₆ / CuCl₂; (S,S)-2,2'-isopropylidenebis(4-tert-butyl-2-oxazoline) / CH₂Cl₂ / 10 h / 25 °C

2: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C

3: KHMDS / tetrahydrofuran; toluene / 0.33 h / -78 °C

4: LiBH₄ / tetrahydrofuran / 4 h / 25 °C

With silver hexafluoroantimonate; lithium borohydride; n-butyllithium; potassium hexamethylsilazane; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; copper dichloride; In tetrahydrofuran; hexane; dichloromethane; toluene; 1: Diels-Alder reaction;
DOI:10.1021/ol051840r

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 870290-82-7
N-{3-[4-(tert-butyl-dimethyl-silanyloxy)-1-hydroxymethyl-3-methyl-2-prop-1-ynyl-cyclohex-3-enyl]-propyl}-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C

1.2: 92 percent / tetrahydrofuran / 0.17 h / -78 °C

2.1: AgSbF₆ / CuCl₂; (S,S)-2,2'-isopropylidenebis(4-tert-butyl-2-oxazoline) / CH₂Cl₂ / 10 h / 25 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C

4.1: KHMDS / tetrahydrofuran; toluene / 0.33 h / -78 °C

5.1: LiBH₄ / tetrahydrofuran / 4 h / 25 °C

With silver hexafluoroantimonate; lithium borohydride; n-butyllithium; sodium hexamethyldisilazane; potassium hexamethylsilazane; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; copper dichloride; In tetrahydrofuran; hexane; dichloromethane; toluene; 2.1: Diels-Alder reaction;
DOI:10.1021/ol051840r

Reference yield:

: 870290-79-2
(6S,7S)-9-(tert-Butyl-dimethyl-silanyloxy)-8-methyl-1-oxo-7-prop-1-ynyl-2-aza-spiro[5.5]undec-8-ene-2-carboxylic acid benzyl ester

: 870290-82-7
N-{3-[4-(tert-butyl-dimethyl-silanyloxy)-1-hydroxymethyl-3-methyl-2-prop-1-ynyl-cyclohex-3-enyl]-propyl}-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C

2: KHMDS / tetrahydrofuran; toluene / 0.33 h / -78 °C

3: LiBH₄ / tetrahydrofuran / 4 h / 25 °C

With lithium borohydride; n-butyllithium; potassium hexamethylsilazane; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/ol051840r