3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-methyl-2-oxo-, hydrazide

Base Information

• Chemical Name: 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-methyl-2-oxo-, hydrazide
• CAS No.: 74693-61-1
• Molecular Formula: C11H11N3O3
• Molecular Weight: 233.227
• Hs Code.: 2933790090
• Mol file: 74693-61-1.mol

Synonyms:1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid hydrazide;4-Hydroxy-1-methyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid hydrazide;4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carbohydrazide;4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid hydrazide;3-quinolinecarboxylic acid,1,4-dihydro-2-hydroxy-1-methyl-4-oxo-,hydrazide;3-Quinolinecarboxylic acid,1,2-dihydro-4-hydroxy-1-methyl-2-oxo-,hydrazide;

Chemical Property of 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-methyl-2-oxo-, hydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 100.84000
• Density: 1.482g/cm³
• LogP: 1.12270

Purity/Quality:

95% ^*data from raw suppliers

4-HYDROXY-1-METHYL-2-OXO-1,2-DIHYDRO-3-QUINOLINE CARBOHYDRAZIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-methyl-2-oxo-, hydrazide

There total 1 articles about 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-methyl-2-oxo-, hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate (57513-54-9) → 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid hydrazide (74693-61-1)

Guidance literature:

With hydrazine hydrate; In ethanol; Ambient temperature;

DOI:10.1007/BF00531325

Reference yield: 93.0%

2-hydroxy-5-methylbenzaldehyde (613-84-3) + 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid hydrazide (74693-61-1) → 4-hydroxy-N'-[(1E)-(2-hydroxy-5-methylphenyl)methylene]-1-methyl-2-oxo-1,2-dihydroquinoline-3-carbohydrazide (1263357-41-0)

Guidance literature:

With phosphoric acid; In dimethyl sulfoxide; at 20 - 100 ℃; for 1.25h;

DOI:10.1016/j.ejmech.2010.08.054

Reference yield: 93.0%

m-Chlorobenzoyl chloride (618-46-2) + 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid hydrazide (74693-61-1) → C18H14ClN3O4 (331963-47-4)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 20 ℃; Cooling;

DOI:10.1007/s10593-009-0198-6

upstream raw materials:

ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

Downstream raw materials:

4-hydroxy-1-methyl-N'-[(1E)-(2-nitrophenyl)methylene]-2-oxo-1,2-dihydroquinoline-3-carbohydrazide

C₁₈H₁₄ClN₃O₄

C₁₈H₁₄N₄O₆

C₁₈H₁₄BrN₃O₄