Technology Process of Carbamic acid,
[(2S)-3-[[(1S)-3-chloro-1-methyl-2-oxopropyl]amino]-2-[[(1,1-dimethyleth
oxy)carbonyl]amino]-3-oxopropyl]-, phenylmethyl ester
There total 3 articles about Carbamic acid,
[(2S)-3-[[(1S)-3-chloro-1-methyl-2-oxopropyl]amino]-2-[[(1,1-dimethyleth
oxy)carbonyl]amino]-3-oxopropyl]-, phenylmethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-{[(benzyloxy)carbonyl]amino}-N-(tert-butoxycarbonyl)-L-alanine;
With
triethylamine; isobutyl chloroformate;
In
tetrahydrofuran;
at -15 ℃;
H-Ala-CH2Cl;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 0 - 20 ℃;
DOI:10.1248/cpb.53.1152
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: [bis(trifluoroacetoxy)iodo]benzene; pyridine / dimethylformamide; H2O
2.1: Basic condition
3.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / -15 °C
3.2: 57.6 percent / tetrahydrofuran; dimethylformamide / 0 - 20 °C
With
pyridine; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; isobutyl chloroformate;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.53.1152
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: Basic condition
2.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / -15 °C
2.2: 57.6 percent / tetrahydrofuran; dimethylformamide / 0 - 20 °C
With
triethylamine; isobutyl chloroformate;
In
tetrahydrofuran;
DOI:10.1248/cpb.53.1152
