Technology Process of 10-Oxa-2,5,8-triazadodecanoic acid,
4-(chloroacetyl)-7,11,11-trimethyl-6,9-dioxo-, phenylmethyl ester,
(4S,7S)-
There total 3 articles about 10-Oxa-2,5,8-triazadodecanoic acid,
4-(chloroacetyl)-7,11,11-trimethyl-6,9-dioxo-, phenylmethyl ester,
(4S,7S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
L-N-Boc-Ala;
With
triethylamine; isobutyl chloroformate;
In
tetrahydrofuran;
H-2,3-diaminopropionic acid(Z)-CH2Cl;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 0 - 20 ℃;
DOI:10.1248/cpb.53.1152
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: HCl / dioxane
2.1: isobutyl chloroformate; triethylamine / tetrahydrofuran
2.2: 56 percent / tetrahydrofuran; dimethylformamide / 0 - 20 °C
With
hydrogenchloride; triethylamine; isobutyl chloroformate;
In
tetrahydrofuran; 1,4-dioxane;
DOI:10.1248/cpb.53.1152
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / -15 °C
1.2: diethyl ether; tetrahydrofuran / -5 °C
1.3: 75.9 percent / HCl / diethyl ether; tetrahydrofuran; dioxane / 0.5 h / -15 °C
2.1: HCl / dioxane
3.1: isobutyl chloroformate; triethylamine / tetrahydrofuran
3.2: 56 percent / tetrahydrofuran; dimethylformamide / 0 - 20 °C
With
hydrogenchloride; triethylamine; isobutyl chloroformate;
In
tetrahydrofuran; 1,4-dioxane;
DOI:10.1248/cpb.53.1152
