GQ-16

Base Information

• Chemical Name: GQ-16
• CAS No.: 870554-67-9
• Molecular Formula: C₁₉H₁₆BrNO₃S
• Molecular Weight: 418.311
• Mol file: 870554-67-9.mol

Synonyms:

Chemical Property of GQ-16

Chemical Property:

• PSA: 71.91000
• LogP: 4.94050
• Solubility.: ≤0.33mg/ml in DMSO;5mg/ml in dimethyl formamide

Purity/Quality:

97% ^*data from raw suppliers

GQ-16 ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Full activation of peroxisome proliferator-activated receptor γ (PPARγ), e.g., using thiazolidinediones, effectively treats insulin resistance and type 2 diabetes but also commonly promotes weight gain, hyperphagia, and edema. GQ-16 is a partial agonist for PPARγ (Ki = 160 nM) which induces adipogenesis significantly less than the full activator rosiglitazone. Like rosiglitazone, GQ-16 reverses high fat diet-mediated impairments in insulin signaling. However, GQ-16 does not induce weight gain, hyperphagia, or edema. GQ-16 does not activate PPARα, PPARβ/δ, or RXRα.

Technology Process of GQ-16

There total 1 articles about GQ-16 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

3-(4-methyl-benzyl)-thiazolidine-2,4-dione (103986-16-9) + 3-(5-bromo-2-methoxy-phenyl)-2-cyano-ethyl acrylate (199179-13-0) → 5-(5-bromo-2-methoxy-benzylidene)-3-(4-methyl-benzyl)-thiazolidine-2,4-dione (870554-67-9)

Guidance literature:

In ethanol; Heating;

DOI:10.1016/j.ejmech.2005.06.002

upstream raw materials:

3-(4-methyl-benzyl)-thiazolidine-2,4-dione

3-(5-bromo-2-methoxy-phenyl)-2-cyano-ethyl acrylate