Benzoic acid, 4-(4-iodobenzoyl)-

Base Information

• Chemical Name: Benzoic acid, 4-(4-iodobenzoyl)-
• CAS No.: 870646-14-3
• Molecular Formula: C14H9IO3
• Molecular Weight: 352.128
• Mol file: 870646-14-3.mol

Synonyms:

Chemical Property of Benzoic acid, 4-(4-iodobenzoyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4-(4-iodobenzoyl)-

There total 4 articles about Benzoic acid, 4-(4-iodobenzoyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-hydroxymethyl-phenyl)-(4-iodo-phenyl)-methanone (870646-23-4) → 4-(4-iodobenzoyl)benzoic acid (870646-14-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / NaHCO₃; Dess-Martin periodinane / CH₂Cl₂ / 5 h

2: 79 percent / 2-methyl-2-butene; NaH₂PO₄; NaOCl₂ / 2-methyl-propan-2-ol; tetrahydrofuran; H₂O / 18 h

With sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium hydrogencarbonate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol; 1: Dess-Martin oxidation;

DOI:10.1021/ol0520166

Reference yield:

[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-(4-iodo-phenyl)-methanol (870646-13-2) → 4-(4-iodobenzoyl)benzoic acid (870646-14-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / HCl / acetonitrile / 1 h

2: 77 percent / NaHCO₃; Dess-Martin periodinane / CH₂Cl₂ / 5 h

3: 79 percent / 2-methyl-2-butene; NaH₂PO₄; NaOCl₂ / 2-methyl-propan-2-ol; tetrahydrofuran; H₂O / 18 h

With hydrogenchloride; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium hydrogencarbonate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; water; acetonitrile; tert-butyl alcohol; 2: Dess-Martin oxidation;

DOI:10.1021/ol0520166

Reference yield:

4-iodo-benzyl alcohol (18282-51-4) → 4-(4-iodobenzoyl)benzoic acid (870646-14-3)

Guidance literature:

Multi-step reaction with 5 steps

1: imidazole / tetrahydrofuran / 12 h / 20 °C

2: 82 percent / t-BuLi / diethyl ether; pentane / 0.08 h / -78 - -50 °C

3: 91 percent / HCl / acetonitrile / 1 h

4: 77 percent / NaHCO₃; Dess-Martin periodinane / CH₂Cl₂ / 5 h

5: 79 percent / 2-methyl-2-butene; NaH₂PO₄; NaOCl₂ / 2-methyl-propan-2-ol; tetrahydrofuran; H₂O / 18 h

With 1H-imidazole; hydrogenchloride; sodium dihydrogenphosphate; 2-methyl-but-2-ene; tert.-butyl lithium; sodium hydrogencarbonate; Dess-Martin periodane; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetonitrile; tert-butyl alcohol; pentane; 4: Dess-Martin oxidation;

DOI:10.1021/ol0520166

upstream raw materials:

(4-hydroxymethyl-phenyl)-(4-iodo-phenyl)-methanone

[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-(4-iodo-phenyl)-methanol

4-iodo-benzyl alcohol

4-(tert-butyldimethylsiloxymethyl)iodobenzene

Downstream raw materials:

C₇₁H₁₁₉⁽³⁾HO₁₀Si₄

C₁₄H₉⁽³⁾HO₃