5-Methoxy-2-methylthiazole

Base Information

• Chemical Name: 5-Methoxy-2-methylthiazole
• CAS No.: 38205-64-0
• Molecular Formula: C₅H₇NOS
• Molecular Weight: 129.183
• Hs Code.: 2934100090
• UNII: 154Z60090O
• DSSTox Substance ID: DTXSID5068077
• Nikkaji Number: J59.611F
• Wikidata: Q27251691
• Metabolomics Workbench ID: 47667
• Mol file: 38205-64-0.mol

Synonyms:5-Methoxy-2-methylthiazole;38205-64-0;2-Methyl-5-methoxythiazole;5-methoxy-2-methyl-1,3-thiazole;Thiazole, 5-methoxy-2-methyl-;FEMA 3192;FEMA No. 3192;BRN 1209888;5-Methoxy-2-methyl-Thiazole;UNII-154Z60090O;154Z60090O;SCHEMBL3506762;DTXSID5068077;FEMA-3192;CHEBI:185906;5-Methoxy-2-methylthiazole, 9CI;AKOS006272284;METHYL-5-METHOXYTHIAZOLE, 2-;LS-2940;2-METHYL-5-METHOXYTHIAZOLE [FHFI];CS-0308014;FT-0691784;EN300-105089;A824052;Q27251691

Chemical Property of 5-Methoxy-2-methylthiazole

Chemical Property:

• Vapor Pressure: 1.08mmHg at 25°C
• Boiling Point: 182.8°Cat760mmHg
• PKA: 3.47±0.10(Predicted)
• Flash Point: 64.4°C
• PSA: 50.36000
• Density: 1.149g/cm³
• LogP: 1.46010
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 129.02483502
• Heavy Atom Count: 8
• Complexity: 78.8

Purity/Quality:

97% ^*data from raw suppliers

2-METHYL-5-METHOXYTHIAZOLE 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=NC=C(S1)OC
• Description: Can be prepared from chloro- (or bromo-) methoxyacetaldehyde and thioacetamide.

Technology Process of 5-Methoxy-2-methylthiazole

There total 1 articles about 5-Methoxy-2-methylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 5-methoxy-2-methyl-thiazole (38205-64-0)

Guidance literature:

/BRN= 99255/, P2S5;

DOI:10.1021/jf60192a009

Reference yield: 86.0%

5-methoxy-2-methyl-thiazole (38205-64-0) + 4-Phenyl-1,2,4-triazolidine-3,5-dione (4233-33-4) → O-methyl 6,7-dihydro-3-methyl-5,7-dioxo-6-phenyl-1H,5H-<1,2,4>triazolo<1,2-a><1,2,4>triazole-1-carbothioate

Guidance literature:

In acetonitrile; for 0.5h; Ambient temperature;

DOI:10.1246/bcsj.65.3315

Reference yield: 8.0%

5-methoxy-2-methyl-thiazole (38205-64-0) + 4-Phenyl-1,2,4-triazolidine-3,5-dione (4233-33-4) → O-methyl 5-methyl-1H-1,2,4-triazole-3-carbothioate + O-methyl 6,7-dihydro-3-methyl-5,7-dioxo-6-phenyl-1H,5H-<1,2,4>triazolo<1,2-a><1,2,4>triazole-1-carboxylate + O-methyl 6,7-dihydro-3-methyl-5,7-dioxo-6-phenyl-1H,5H-<1,2,4>triazolo<1,2-a><1,2,4>triazole-1-carbothioate

Guidance literature:

With zinc(II) chloride; In acetonitrile; at 25 ℃; for 40h;

DOI:10.1246/bcsj.65.3315