Technology Process of 1-Oxa-spiro[4.5]dec-7-ene
There total 6 articles about 1-Oxa-spiro[4.5]dec-7-ene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; p-toluenesulfonyl chloride;
1.) 0 deg C , 1.5 h, 2.) room temperature, 1.5 h;
DOI:10.1021/jo00019a019
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 85 percent / hydroquinone / 4 h / 155 °C
2: 91 percent / CuBr, Vitride, 1-butanol / tetrahydrofuran / 1.) -78 deg C, 15 min, 2.) -20 deg C, 2 h
3: 79 percent / LiBH4 / tetrahydrofuran / 36 h / Ambient temperature
4: 77.8 percent / tosyl chloride, anhydrous pyridine / 1.) 0 deg C , 1.5 h, 2.) room temperature, 1.5 h
With
pyridine; lithium borohydride; hydroquinone; p-toluenesulfonyl chloride; sodium bis(2-methoxyethoxy)aluminium dihydride; copper(I) bromide; butan-1-ol;
In
tetrahydrofuran;
DOI:10.1021/jo00019a019
