FILGRASTIM

Base Information

• Chemical Name: FILGRASTIM
• CAS No.: 121181-53-1
• Molecular Formula: W99
• Molecular Weight: 0
• Hs Code.: 3002905150

Synonyms:Figrastim;Filgrastim;GRAN 300;Gran injection 150;Granulokine;KRN 8601;Leucostim;MBRI 9901;Neupogen;R-metHuG-CSF;Recombinant methionyl human G-CSF;XM 02;rHG-CSF;

Chemical Property of FILGRASTIM

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: -70°C

Purity/Quality:

99%, ^*data from raw suppliers

Filgrastim ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Filgrastim is a recombinant human granulocyte colony stimulating factor (G-CSF) indicated as an adjunct to cancer chemotherapy for patients with non-myeloid malignancies. It reduces the duration of chemotherapy-induced neutropenia by forcing immature leucocytes to differentiate into neutrophils, thereby decreasing the incidence and length of infections.Bone pain is the most significant side effect.Chugai launched the second G-CSF, lenograstim, in December 1991. Other potential uses include bone marrow transplants, myelodysplastic syndromes and febrilelchronic neutropenia.
• Uses: Antineutropenic; hematopoietic stimulant. Filgrastim is a human granulocyte colony stimulating factor (G-CSF) used to treat neutropenia.
• Indications: Filgrastim (Neupogen) is a human recombinant granulocyte colony–stimulating factor (rG-CSF) produced using recombinant DNA technology. It acts on precursor hematopoietic cells in the bone marrow by binding to specific receptors that stimulate cellular proliferation and differentiation into neutrophils. It also enhances some neutrophil functions, including phagocytosis and antibody-dependent killing.
• Clinical Use: Filgrastim, G-CSF, Neupogen, stimulates the proliferation ofgranulocytes (especially neutrophils) by mobilizinghematopoietic stem cells in the bone marrow. The native protein is glycosylated.Filgrastim selectively stimulates proliferation and differentiationof neutrophil precursors in the bone marrow. Thisleads to the release of mature neutrophils into the circulationfrom the bone marrow. Filgrastim also affects mature neutrophilsby enhancing phagocytic activity, priming the cellularmetabolic pathways associated with the respiratoryburst, enhancing antibody-dependent killing, and increasingthe expression of some functions associated with cell surfaceantigens.In patients receiving chemotherapy with drugs such ascyclophosphamide, doxorubicin, and etoposide, the incidenceof neutropenia accompanied by fever is rather high.Administration of G-CSF reduces the time of neutrophilrecovery and duration of fever in adults with acute myelogenousleukemia. The number of infections, days thatantibiotics are required, and duration of hospitalization arealso reduced. Filgrastim is used to accelerate recovery of neutrophils after chemotherapy, both to prevent infections and to shorten the duration of neutropenia in patients in whom infections have developed.
• Drug interactions: Potentially hazardous interactions with other drugs Cytotoxics: neutropenia possibly exacerbated with capecitabine, fluorouracil and tegafur.

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