Carbamic acid, [4-[6-[[4-[2-oxo-2-[(triphenylmethoxy)amino]ethyl]-5-phenyl-2-thienyl]carb onyl]-2-phenyl-1H-indol-1-yl]butyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [4-[6-[[4-[2-oxo-2-[(triphenylmethoxy)amino]ethyl]-5-phenyl-2-thienyl]carb onyl]-2-phenyl-1H-indol-1-yl]butyl]-, 1,1-dimethylethyl ester
CAS No.:875272-00-7
Molecular Formula:C55H51N3O5S
Molecular Weight:866.093
Hs Code.:

Carbamic acid,
[4-[6-[[4-[2-oxo-2-[(triphenylmethoxy)amino]ethyl]-5-phenyl-2-thienyl]carb
onyl]-2-phenyl-1H-indol-1-yl]butyl]-, 1,1-dimethylethyl ester

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Chemical Property of Carbamic acid, [4-[6-[[4-[2-oxo-2-[(triphenylmethoxy)amino]ethyl]-5-phenyl-2-thienyl]carb onyl]-2-phenyl-1H-indol-1-yl]butyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [4-[6-[[4-[2-oxo-2-[(triphenylmethoxy)amino]ethyl]-5-phenyl-2-thienyl]carb onyl]-2-phenyl-1H-indol-1-yl]butyl]-, 1,1-dimethylethyl ester

There total 11 articles about Carbamic acid, [4-[6-[[4-[2-oxo-2-[(triphenylmethoxy)amino]ethyl]-5-phenyl-2-thienyl]carb onyl]-2-phenyl-1H-indol-1-yl]butyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 875271-91-3
[5-(1-{4-[(tert-butoxycarbonyl)amino]butyl}-2-phenyl-1H-indole-6-carbonyl)-2-phenylthiophene-3-yl]acetic acid

: 31938-11-1
O-tritylhydroxylamine

: 875272-00-7
(4-{2-phenyl-6-[5-phenyl-4-(trityloxycarbamoyl-methyl)-thiophene-2-carbonyl]-indol-1-yl}-butyl)-carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2005.08.018

Reference yield:

: 875271-79-7
(2-phenylthiophen-3-yl)acetic acid methyl ester

: 875272-00-7
(4-{2-phenyl-6-[5-phenyl-4-(trityloxycarbamoyl-methyl)-thiophene-2-carbonyl]-indol-1-yl}-butyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / AlCl₃ / CH₂Cl₂ / 20 °C

2: 96 percent / stannous chloride dihydrate / ethyl acetate / 0.5 h / Heating

3: 98 percent / Et₂NH; CuI / Pd(PPh₃)4 / 4 h / 20 °C

4: 61 percent / PdCl₂(PhCN)2 / dimethylformamide / 0.5 h / 80 °C

5: 33 percent Turnov_. / CsF on Celite / acetonitrile / 48 h / Heating

6: 75 percent / NaOH / methanol / 2.5 h / Heating

7: 57 percent / HATU; N-hydroxybenzotriazole; ethyldiisopropylamine / CH₂Cl₂ / 0.5 h / 20 °C

With sodium hydroxide; copper(l) iodide; aluminium trichloride; benzotriazol-1-ol; diethylamine; N-ethyl-N,N-diisopropylamine; cesium fluoride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tin(ll) chloride; bis(benzonitrile)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 1: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2005.08.018

Reference yield:

: 875271-86-6
(2-phenylthiophen-3-yl)acetic acid ethyl ester

: 875272-00-7
(4-{2-phenyl-6-[5-phenyl-4-(trityloxycarbamoyl-methyl)-thiophene-2-carbonyl]-indol-1-yl}-butyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: KOH / methanol / 3 h / Heating

2: 3.3 g / HCl / 5 h / Heating

3: 74 percent / AlCl₃ / CH₂Cl₂ / 20 °C

4: 96 percent / stannous chloride dihydrate / ethyl acetate / 0.5 h / Heating

5: 98 percent / Et₂NH; CuI / Pd(PPh₃)4 / 4 h / 20 °C

6: 61 percent / PdCl₂(PhCN)2 / dimethylformamide / 0.5 h / 80 °C

7: 33 percent Turnov_. / CsF on Celite / acetonitrile / 48 h / Heating

8: 75 percent / NaOH / methanol / 2.5 h / Heating

9: 57 percent / HATU; N-hydroxybenzotriazole; ethyldiisopropylamine / CH₂Cl₂ / 0.5 h / 20 °C

With hydrogenchloride; potassium hydroxide; sodium hydroxide; copper(l) iodide; aluminium trichloride; benzotriazol-1-ol; diethylamine; N-ethyl-N,N-diisopropylamine; cesium fluoride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tin(ll) chloride; bis(benzonitrile)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 3: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2005.08.018