6-Dsmb-naltrexone

Base Information

Chemical Name:6-Dsmb-naltrexone
CAS No.:92398-20-4
Molecular Formula:C₂₄H₂₇NO₅
Molecular Weight:409.482
Hs Code.:
DSSTox Substance ID:DTXSID50919198

Synonyms:(3,6beta,14-tri-OH)(6alpha-carboxy)-isomer of 3,6,14-trihydroxy-6-(2-carboxyallyl)-17-(cyclopropylmethyl)morphinan gamma-lactone 4,5-epoxide;3,6,14-trihydroxy-6-(2-carboxyallyl)-17-(cyclopropylmethyl)morphinan gamma-lactone 4,5-epoxide;6-DSMB-naltrexone

Suppliers and Price of 6-Dsmb-naltrexone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 6-Dsmb-naltrexone

Chemical Property:

Boiling Point:651.7°Cat760mmHg
Flash Point:347.9°C
PSA：79.23000
Density:1.47g/cm³
LogP:2.13610
XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:409.18892296
Heavy Atom Count:30
Complexity:826

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C=C1CC2(CCC3(C4CC5=C6C3(C2OC6=C(C=C5)O)CCN4CC7CC7)O)OC1=O
Isomeric SMILES:C=C1CC2(CC[C@]3([C@H]4CC5=C6[C@]3([C@H]2OC6=C(C=C5)O)CCN4CC7CC7)O)OC1=O

Technology Process of 6-Dsmb-naltrexone

There total 3 articles about 6-Dsmb-naltrexone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 92398-21-5
4,5α-epoxy-3,6α,14-trihydroxy-6β-(2-carboxyallyl)-17-(cyclopropylmethyl)morphinan γ-lactone 14-acetate ester

: 92398-20-4
4,5α-epoxy-3,6α,14-trihydroxy-6β-(2-carboxyallyl)-17-(cyclopropylmethyl)morphinan γ-lactone

Guidance literature:: In methanol; at 45 ℃; for 20h;
DOI:10.1021/jm00378a032

Reference yield:

: 16590-41-3
Naltrexone

: 92398-20-4
4,5α-epoxy-3,6α,14-trihydroxy-6β-(2-carboxyallyl)-17-(cyclopropylmethyl)morphinan γ-lactone

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / 0.5 h / 105 °C

2: 64 percent / activated zinc / tetrahydrofuran / 2.5 h / 40 - 45 °C

3: 83 percent / methanol / 20 h / 45 °C

With zinc; In tetrahydrofuran; methanol;
DOI:10.1021/jm00378a032

Reference yield:

: 92398-19-1
4,5α-epoxy-3,14-diacetoxy-6-oxo-17-(cyclopropylmethyl)morphinan

: 92398-20-4
4,5α-epoxy-3,6α,14-trihydroxy-6β-(2-carboxyallyl)-17-(cyclopropylmethyl)morphinan γ-lactone

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / activated zinc / tetrahydrofuran / 2.5 h / 40 - 45 °C

2: 83 percent / methanol / 20 h / 45 °C

With zinc; In tetrahydrofuran; methanol;
DOI:10.1021/jm00378a032