2,4,7,12-Tetraazatridecan-13-oic acid, 2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-10-[2-methyl- 1-[(2-methylpropyl)thio]propoxy]-3,6-dioxo-8,11-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (5S,8S,10S,11S)-

Base Information

Chemical Name:2,4,7,12-Tetraazatridecan-13-oic acid, 2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-10-[2-methyl- 1-[(2-methylpropyl)thio]propoxy]-3,6-dioxo-8,11-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (5S,8S,10S,11S)-
CAS No.:875436-09-2
Molecular Formula:C45H64N6O5S3
Molecular Weight:865.238
Hs Code.:

2,4,7,12-Tetraazatridecan-13-oic acid,
2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-10-[2-methyl-
1-[(2-methylpropyl)thio]propoxy]-3,6-dioxo-8,11-bis(phenylmethyl)-,
5-thiazolylmethyl ester, (5S,8S,10S,11S)-

Synonyms:

Suppliers and Price of 2,4,7,12-Tetraazatridecan-13-oic acid, 2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-10-[2-methyl- 1-[(2-methylpropyl)thio]propoxy]-3,6-dioxo-8,11-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (5S,8S,10S,11S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,4,7,12-Tetraazatridecan-13-oic acid, 2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-10-[2-methyl- 1-[(2-methylpropyl)thio]propoxy]-3,6-dioxo-8,11-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (5S,8S,10S,11S)-

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Technology Process of 2,4,7,12-Tetraazatridecan-13-oic acid, 2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-10-[2-methyl- 1-[(2-methylpropyl)thio]propoxy]-3,6-dioxo-8,11-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (5S,8S,10S,11S)-

There total 1 articles about 2,4,7,12-Tetraazatridecan-13-oic acid, 2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-10-[2-methyl- 1-[(2-methylpropyl)thio]propoxy]-3,6-dioxo-8,11-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (5S,8S,10S,11S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 592-65-4
diisobutyl sulfide

: 155213-67-5
ritonavir

: 875436-09-2
N₁-((1S,3S,4S)-1-benzyl-3-[1-(isobutylthio)-2-methylpropoxy]-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentyl)-N₂-{[[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)amino]carbonyl}-L-valinamide

Guidance literature:: With dibenzoyl peroxide; In acetonitrile; at 0 - 20 ℃; for 2.33333h;
DOI:10.1021/jm900080g

Reference yield: 52.0%

: 875436-09-2
N₁-((1S,3S,4S)-1-benzyl-3-[1-(isobutylthio)-2-methylpropoxy]-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentyl)-N₂-{[[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)amino]carbonyl}-L-valinamide

: disodium N₁-((1S,3S,4S)-1-benzyl-3-[2-methyl-1-(phosphonatooxy)propoxy]-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentyl)-N₂-{[[(2-isopropyl-1,3-thiazol-4-yl)methyl]-(methyl)amino]carbonyl}-L-valinamide

Guidance literature:: N₁-((1S,3S,4S)-1-benzyl-3-[1-(isobutylthio)-2-methylpropoxy]-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentyl)-N₂-{[[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)amino]carbonyl}-L-valinamide; With N-iodo-succinimide; phosphoric acid; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Molecular sieve;

With sodium carbonate; In water; N,N-dimethyl-formamide; pH=9;

Reference yield:

: 875436-09-2
N₁-((1S,3S,4S)-1-benzyl-3-[1-(isobutylthio)-2-methylpropoxy]-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentyl)-N₂-{[[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)amino]carbonyl}-L-valinamide

: 875515-96-1
C₄₁H₅₇N₆O₉PS₂

Guidance literature:: With N-iodo-succinimide; phosphoric acid; In N,N-dimethyl-formamide; at 0 - 20 ℃; Molecular sieve;
DOI:10.1021/jm900080g