Chemical Property of (E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide
Chemical Property:
- Vapor Pressure:6.56E-10mmHg at 25°C
- Melting Point:165-167℃
- Boiling Point:494.2°Cat760mmHg
- Flash Point:252.7°C
- PSA：38.33000
- Density:1.265g/cm3
- LogP:4.07350
- Storage Temp.:Store at RT
- Solubility.:DMSO: 13 mg/mL, soluble
- XLogP3:4.2
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:4
- Exact Mass:287.0713064
- Heavy Atom Count:20
- Complexity:337
- Purity/Quality:
-
99%, *data from raw suppliers
SB366791 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
22-24/25
- MSDS Files:
-
Useful:
- Canonical SMILES:COC1=CC=CC(=C1)NC(=O)C=CC2=CC=C(C=C2)Cl
-
Description
SB-366791 (472981-92-3) is a potent (IC50 = 0.7 μM) and selective TRPV1 blocker.1,2 Selective for TRPV1 in a panel of 47 different binding assays.
-
Uses
N-(4-Methoxyphenyl)-4-chlorocinnamamide is a novel, potent, and selective cinnamide TRPV1 antagonist. Also a useful tool to further study the biology of TRPV1. SB-366791 has been used as a transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonist: to infer the in vitro and in vivo pharmacology of (E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (AMG 9810) to study its effects on sodium hydrogen sulfide (NaHS) or capsaicin-induced contractile activityto study the inhibitory potency of phoneutria toxin (PnTx3-5) (native and recombinant) on various responses mediated by transient receptor potential cation channel subfamily V member 1 (TRPV1)
