Technology Process of Carbonic acid,
2-ethyl-3,7-dimethyl-6-[4-(trifluoromethoxy)phenoxy]-4-quinolinyl methyl
ester
There total 5 articles about Carbonic acid,
2-ethyl-3,7-dimethyl-6-[4-(trifluoromethoxy)phenoxy]-4-quinolinyl methyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium t-butanolate;
In
ISOPROPYLAMIDE;
at 20 ℃;
Product distribution / selectivity;
Reflux;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / ISOPROPYLAMIDE / 37 h / 100 - 105 °C / Inert atmosphere
2.1: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 6 h / 30 °C / 3750.38 Torr
3.1: toluene-4-sulfonic acid / xylene / Inert atmosphere; Reflux
3.2: 20 - 80 °C
4.1: sodium hydride; calcium chloride / N,N-dimethyl-formamide / 50 h / 15 °C / Inert atmosphere; Reflux
4.2: 15 - 20 °C
With
hydrogen; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; calcium chloride;
5% Pd(II)/C(eggshell);
In
methanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide; xylene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 6 h / 30 °C / 3750.38 Torr
2.1: toluene-4-sulfonic acid / xylene / Inert atmosphere; Reflux
2.2: 20 - 80 °C
3.1: sodium hydride; calcium chloride / N,N-dimethyl-formamide / 50 h / 15 °C / Inert atmosphere; Reflux
3.2: 15 - 20 °C
With
hydrogen; sodium hydride; toluene-4-sulfonic acid; calcium chloride;
5% Pd(II)/C(eggshell);
In
methanol; N,N-dimethyl-formamide; xylene;
